(44 customer reviews)

Aciclovir is an antiviral drug. Aciclovir is used to treat viral infections such as cold sores, to stop the growth of Herpes simplex virus, Varicella zoster virus, etc.

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Side effect

The drug is usually well tolerated.

The following classification of adverse reactions is used depending on the frequency of occurrence: very often (>1/10), often (>1/10, <1/100), sometimes (>1/1000, <1/100), rarely (>1/10 000, <1/1000), very rarely (<1/10 000).

From the digestive system: often – nausea, vomiting, diarrhea; very rarely – hepatitis, jaundice, in isolated cases – abdominal pain.

From the hematopoiesis system: rarely – a transient slight increase in the activity of liver enzymes, a slight increase in the concentration of urea and creatinine, hyperbilirubinemia; very rarely – leukopenia, erythropenia, anemia, thrombocytopenia.

From the Central nervous System: often – headache, dizziness; very rarely – agitation, confusion, tremor, ataxia, dysarthria, hallucinations, psychotic symptoms, convulsions, drowsiness, encephalopathy, coma.

Usually these side effects were observed in patients with renal insufficiency or in the presence of other provoking factors, and were mostly reversible.

From the respiratory system: rarely – shortness of breath.

Allergic reactions: anaphylactic reactions, skin rash, itching, urticaria, Lyell’s syndrome, Stevens-Johnson syndrome.

From the skin and subcutaneous tissue: often – itching, urticaria, rash, including sensitization, rarely – alopecia, rapid diffuse hair loss (since this type of alopecia is observed in various diseases and with therapy with many medications, its connection with taking acyclovir has not been established); very rarely Lyell’s syndrome, Stevens-Johnson syndrome.

Other: often – fatigue, fever; rarely – peripheral edema, visual impairment, lymphadenopathy, myalgia, malaise.

Contraindications to use

lactation period; children under 3 years of age (for this dosage form).

With caution: pregnancy; elderly people and patients taking large doses of acyclovir, especially against the background of dehydration; impaired renal function; neurological disorders or neurological reactions to taking cytotoxic drugs (including in the anamnesis).

Use during pregnancy and lactation

Acyclovir penetrates the placental barrier and accumulates in breast milk. The use of the drug during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus. If it is necessary to take acyclovir during lactation, an interruption of breastfeeding is required.

Use in cases of impaired renal function

Take with caution in case of impaired renal function.

Caution should be exercised when prescribing acyclovir to patients with renal insufficiency. In such patients, ingestion of the drug in recommended doses for the treatment and prevention of infections caused by the herpes simplex virus does not lead to accumulation of the drug to concentrations exceeding the established safe levels. However, in patients with severe renal insufficiency (CC less than 10 ml/min) the dose of acyclovir should be reduced to 200 mg 2 times / day at 12-hour intervals.

44 reviews for Aciclovir

  1. Daniel Salinas

  2. Cynthia Hale

  3. Jacqueline Bennett

  4. Rose Barber

  5. Kathryn McGuire

  6. Philip Burke

  7. John Roy

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