(50 customer reviews)

Actos (Pioglitazone) is used to control high blood sugar in type 2 diabetes (non-insulin-dependent diabetes mellitus).

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Pharmacological action

Actos is an oral antidiabetic agent containing pioglitazone, an active component of the thiazolidinedione group, which has a pronounced hypoglycemic effect in type II diabetes mellitus. The mechanism of action of pioglitazone depends on the presence of insulin. Actos is an agonist of gamma receptors with high selectivity, which are activated by PPAR-gamma. PPAR-gamma receptors are found in muscle and adipose tissue, as well as liver tissues, activation of these receptors modulates the transcription of a number of genes that are sensitive to insulin and are involved in glucose control and lipid metabolism. The drug Actos helps to reduce the insulin resistance of peripheral tissues and the liver, as a result of which there is an increase in the consumption of insulin-dependent glucose and a decrease in the release of glucose from the liver. Unlike sulfonylureas, Actos does not stimulate insulin production by the pancreas. In patients with type 2 diabetes mellitus, when taking the drug Actos, a decrease in insulin resistance is recorded, which leads to a decrease in serum glucose and a decrease in plasma insulin levels, as well as a decrease in glycated hemoglobin. There is a significant improvement in glycemic control in people with type 2 diabetes mellitus with combined therapy with Actos and sulfonylurea derivatives, metformin or insulin. In patients with type 2 diabetes mellitus with concomitant lipid metabolism disorder, a decrease in serum triglyceride levels and an increase in high-density lipoprotein levels are recorded during therapy with Actos, without changing the indicators of total cholesterol and low-density lipoproteins.


An overdose of the drug ACTOS with monotherapy is not accompanied by the appearance of specific clinical symptoms. An overdose of ACTOS in combination with a sulfonylurea preparation may be accompanied by the development of symptoms of hypoglycemia. There is no specific treatment for overdose. Symptomatic therapy is required (for example, treatment of hypoglycemia).

50 reviews for Actos

  1. Carl Gibbs

  2. Raymond Buckley

  3. Timothy Flores

  4. Mary Bailey

  5. Walter Gallegos

  6. Jason Lloyd

  7. Grace Wise

  8. Zachary Figueroa

  9. Keith Bean

  10. Megan Browning

  11. Joseph Montgomery

  12. Lawrence Nava

  13. Linda Cordova

  14. Maria Espinoza

  15. Marilyn Gardner

  16. Heather Hodge

  17. Elijah Compton

  18. Matthew Bautista

  19. Maria Webster

  20. Angela Carlson

  21. Lisa Lee

  22. Roger Love

  23. Michelle Gomez

  24. Olivia Foster

  25. Jordan Phelps

  26. Paul Blevins

  27. Peter Duarte

  28. Judith McCann

  29. Arthur Jacobson

  30. Amanda Carroll

  31. Gregory Rodriguez

  32. Paul Chambers

  33. Linda Daniel

  34. Janet Lynn

  35. Christine Marks

  36. David Frazier

  37. Philip Farmer

  38. Raymond Duffy

  39. Eric Everett

  40. Roy Wu

  41. Barbara Payne

  42. Linda Perkins

  43. Terry Burch

  44. Harold Benton

  45. Janice Guzman

  46. Vincent Snyder

  47. James Zuniga

  48. Steven Parks

  49. Thomas Harrington

  50. Jerry Skinner

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