Description
Looking for a drugstore where you can buy Actos online? You can click on the button and go to the drugstore with the cheepest prices. Anonymous delivery, quality medications, absolutely confidentiality. Go to an online pharmacy and select the appropriate Actos dosage, and then the required number of tablets. The purchase process will be as secure and safe as possible. You can also purchase Actos with fast delivery at the drugstore, the medicine will be delivered tomorrow. The getting is made without a prescription because we trust you and understand that you already know which medicine you need.
Pharmacological action
Actos is an oral antidiabetic agent containing pioglitazone, an active component of the thiazolidinedione group, which has a pronounced hypoglycemic effect in type II diabetes mellitus. The mechanism of action of pioglitazone depends on the presence of insulin. Actos is an agonist of gamma receptors with high selectivity, which are activated by PPAR-gamma. PPAR-gamma receptors are found in muscle and adipose tissue, as well as liver tissues, activation of these receptors modulates the transcription of a number of genes that are sensitive to insulin and are involved in glucose control and lipid metabolism. The drug Actos helps to reduce the insulin resistance of peripheral tissues and the liver, as a result of which there is an increase in the consumption of insulin-dependent glucose and a decrease in the release of glucose from the liver. Unlike sulfonylureas, Actos does not stimulate insulin production by the pancreas. In patients with type 2 diabetes mellitus, when taking the drug Actos, a decrease in insulin resistance is recorded, which leads to a decrease in serum glucose and a decrease in plasma insulin levels, as well as a decrease in glycated hemoglobin. There is a significant improvement in glycemic control in people with type 2 diabetes mellitus with combined therapy with Actos and sulfonylurea derivatives, metformin or insulin. In patients with type 2 diabetes mellitus with concomitant lipid metabolism disorder, a decrease in serum triglyceride levels and an increase in high-density lipoprotein levels are recorded during therapy with Actos, without changing the indicators of total cholesterol and low-density lipoproteins.
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