(30 customer reviews)

Aldactone is a diuretic (water pill) indicated to treat hypertension, fluid retention associated with congestive heart failure, cirrhosis, and nephrotic syndrome.

SKU: Aldactone Categories: ,
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How to use: dosage and course of treatment

Inside. With cirrhosis of the liver with a coefficient of Na + / K + less than 1, the daily dose is 100 mg, if the coefficient is more than 1 – 200-400 mg / day. In nephrotic syndrome: 100-200 mg / day in combination with thiazide diuretics. With edematous syndrome: 100-200 mg / day in 2-3 doses, in combination with a “loop” or thiazide diuretic. It is prescribed daily for 5 days, then, depending on the effect, the daily dose is reduced to 25-35 mg or gradually increased to 200-400 mg in 2-4 doses. With arterial hypertension: 50-100 mg / day, once, or in 2-4 doses for 2 weeks in combination with hypotensive drugs, and then the dose is gradually increased every 2 weeks to 200 mg / day. With hypokalemia: 25-100 mg, once, or in several doses (the maximum daily dose is 400 mg). With primary hyperaldosteronism: in the period of preparation for surgery – 100-400 mg / day in 2-4 doses; if it is impossible (or refused) to perform surgery – long-term treatment with minimal effective doses. As a diagnostic tool: 400 mg / day in several doses for 4 days (short test) or for 3-4 weeks (long test). Idiopathic hyperaldosteronism – 100 mg / day. Correction of the dosage regimen is carried out taking into account the concentration of K + in plasma. With severe hyperaldosteronism and a reduced K + content in plasma, a daily dose of 300 mg is prescribed in 2-3 doses (up to 400 mg / day), with an improvement in the condition, the dose is gradually reduced to 25 mg / day. With polycystic ovary syndrome and hirsutism – 100 mg 2 times a day. Children with edematous syndrome: 1-3.3 mg / kg or 30-90 mg / sq.m per day, once or in 1-4 doses. After 5 days, the dose is adjusted and, if necessary, increased 3 times from the initial dose.

Pharmacological action

A potassium-sparing diuretic, the effect of which is due to antagonism with aldosterone (MKS hormone of the adrenal cortex), which promotes the reabsorption of Na+ in the renal tubules and the excretion of K+. Spironolactone (the active substance of the drug) is a competitive antagonist of aldosterone in its effect on the distal parts of the nephron (competes for binding sites on cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent site of collecting tubules and distal tubules), increases the excretion of Na+, Cl- and water and reduces the excretion of K+ and urea, reduces the titrated acidity of urine. Increased diuresis causes a hypotensive effect, which is unstable. The diuretic effect manifests itself on day 2-5 of treatment.

30 reviews for Aldactone

  1. Andrew Valentine

  2. Bruce Webster

  3. Frances McCarty

  4. Alan Parsons

  5. Richard Buckley

  6. Arthur Mendoza

  7. Anthony Butler

  8. Alice Moses

  9. Douglas Gomez

  10. Joe Bauer

  11. Betty Jacobson

  12. Larry Dennis

  13. Denise Reilly

  14. Lisa Santos

  15. Sara Shannon

  16. Steven Hawkins

  17. Michelle Duke

  18. Janet Patton

  19. Patricia Mendoza

  20. Jose Robbins

  21. Andrew Juarez

  22. Virginia Guzman

  23. Larry Ray

  24. Anthony Rogers

  25. Elizabeth Hicks

  26. Donna Reese

  27. Angela Sexton

  28. Victoria Cabrera

  29. Juan Roy

  30. Melissa Willis

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