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They are set individually depending on the severity of the course, the localization of the infection and the sensitivity of the pathogen.
When taken orally, a single dose for adults is 250-500 mg, the daily dose is 1-3 g. The maximum daily dose is 4 g.
For children, the drug is prescribed in a daily dose of 50-100 mg / kg, for children with a body weight of up to 20 kg – 12.5-25 mg / kg.
The daily dose is divided into 4 doses. The duration of treatment depends on the severity of the infection and the effectiveness of treatment.
Tablets are taken orally regardless of food intake.
To prepare the suspension, 62 ml of distilled water is added to the powder bottle. The finished suspension is dosed with a special spoon having 2 labels: the lower one corresponds to 2.5 ml (125 mg), the upper one – 5 ml (250 mg). The suspension should be washed down with water.
With parenteral administration (i / m, I / v jet or IV drip), a single dose for adults is 250-500 mg, the daily dose is 1-3 g; with severe infections, the daily dose can be increased to 10 g or more.
For newborn children, the drug is prescribed in a daily dose of 100 mg / kg, for children of other age groups – 50 mg / kg. In severe infection, these doses can be doubled.
The daily dose is divided into 4-6 injections with an interval of 4-6 hours . The duration of intravenous administration is 7-14 days. The duration of intravenous use is 5-7 days, followed by a transition (if necessary) to an intravenous injection.
The solution for intravenous administration is prepared by adding 2 ml of water for injection to the contents of the vial.
For intravenous injection, a single dose of the drug (no more than 2 g) is dissolved in 5-10 ml of water for injection or isotonic sodium chloride solution and administered slowly for 3-5 minutes (1-2 g for 10-15 minutes). With a single dose exceeding 2 g, the drug is administered intravenously. To do this, a single dose of the drug (2-4 g) is dissolved in 7.5-15 ml of water for injection, then the resulting solution is added to 125-250 ml of isotonic sodium chloride solution or 5-10% glucose solution and injected at a rate of 60-80 drops / min. When administered intravenously to children, 5-10% glucose solution (30-50 ml, depending on age) is used as a solvent.
Solutions are used immediately after preparation.
Allergic reactions: skin rash, urticaria, Quincke’s edema, itching, exfoliative dermatitis, erythema multiforme; in rare cases, anaphylactic shock.
From the digestive system: nausea, vomiting, diarrhea, glossitis, stomatitis, pseudomembranous colitis, intestinal dysbiosis, increased activity of hepatic transaminases.
From the hematopoiesis system: anemia, leukopenia, thrombocytopenia, agranulocytosis.
Effects due to chemotherapeutic action: oral candidiasis, vaginal candidiasis.
Contraindications to use
hypersensitivity to antibiotics from the penicillin group and other betalactam antibiotics; severe liver dysfunction (for parenteral use).
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