Description

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Side effect

From the digestive system: diarrhea, nausea, vomiting, heartburn, abdominal pain, loss of appetite, dry mouth, stomatitis, increased activity of liver enzymes.

From the nervous system: headache, depression, dizziness, sleep disorders, paresthesia, tremor, tinnitus.

Allergic reactions: skin rash, itching, erythema.

From the cardiovascular system: palpitations, tachycardia, arterial hypertension or hypotension, chest pain, shortness of breath.

From the urinary system: proteinuria, hematuria, crystalluria, oliguria, anuria.

From the hematopoiesis system: anemia, leukopenia, agranulocytosis, thrombocytopenia; hypoprothrombinemia.

Other: alopecia, a decrease in the production of tear fluid.

Contraindications to use

Blood diseases, severe liver and/or kidney dysfunction, gastric ulcer or duodenal ulcer in the acute phase, blood clotting disorders, children under 2 years of age, hypersensitivity to salicylates.

Use during pregnancy and lactation

In the first trimester of pregnancy, use is possible only for strict indications. If the individual course of the disease allows, then in the last 2-4 weeks of pregnancy, mesalazine should be discontinued.

If it is necessary to use during lactation, the issue of stopping breastfeeding should be resolved, due to the lack of sufficient clinical experience with the use of mesalazine in this category of patients.

Use in cases of impaired liver function

It is contraindicated in severe violations of liver function.

It is used with caution for liver diseases.

Use in cases of impaired renal function

It is contraindicated in severe renal dysfunction.

It is used with caution for kidney diseases.

Use in children

Contraindicated in children under 2 years of age. Use in children under 2 years of age is possible only if the intended benefit of therapy exceeds the potential risk to the child.

Special instructions

With caution, it is used for liver and kidney diseases, glucose-6-phosphate dehydrogenase deficiency, allergic diseases and predisposition to them. Before the start of treatment, and then monthly during the first 3 months of treatment, peripheral blood picture, liver function, as well as determination of the concentration of urea and creatinine in the blood should be monitored. Patients who are “slow acetylators” have an increased risk of side effects.

Use in children under the age of 2 years is possible only if the intended benefit of therapy exceeds the potential risk to the child.