Brand Levitra

(49 customer reviews)

Brand Levitra causes widening and relaxation of the blood vessels carrying blood to the penis.

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Description

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Pharmacological properties of Levitra 

A remedy for the treatment of erectile dysfunction. The physiological mechanism of penile erection consists in the relaxation of the smooth muscles of the cavernous body and arterioles. During sexual stimulation, nitric oxide (NO) is released from the nerve endings of the cavernous body, activating the enzyme guanylate cyclase and contributing to an increase in the content of cyclic guanosine monophosphate (cGMP), resulting in relaxation of the smooth muscles of the cavernous body, causing an increase in blood flow to the penis. Vardenafil blocks a specific type 5 phosphodiesterase (PDE-5), under the action of which cGMP cleavage occurs. This contributes to the strengthening of the action of endogenous NO in the cavernous body during sexual arousal. Thus, when using Levitra restores the disturbed erection and provides a natural response to sexual stimulation. Vardenafil is rapidly absorbed after ingestion. The concentration in the blood plasma after ingestion on an empty stomach reaches a maximum value for 30-120 minutes (on average after 60 minutes). Absolute bioavailability is about 15%. When taking vardenafil with fatty foods, its absorption rate decreases, the period of reaching the maximum concentration increases to 60 minutes, the maximum concentration in blood plasma decreases by an average of 20%; but there are no significant changes in the AUC index. When taking vardenafil with food containing no more than 30% fat, the pharmacokinetic parameters of the drug do not change. Vardenafil and its main metabolite bind approximately 95% to plasma proteins, and this process is reversible and does not depend on the concentration of the drug. In the sperm of healthy men, 90 minutes after taking vardenafil, no more than 0.00012% of the dose taken is determined. Vardenafil is metabolized mainly under the influence of liver enzymes CYP 3A4 (main pathway), CYP 3A5 and CYP 2C9 (minor pathway). The total clearance of vardenafil is 56 l/h. After oral administration, vardenafil is excreted as metabolites, mainly with feces (91-95% of the administered dose), to a lesser extent – with urine (2-6% of the dose). The half-life of vardenafil is on average 4-5 hours, the main metabolite M1 is about 4 hours. In healthy men aged 65 years and older compared with younger patients (up to 45 years) there was an increase in the AUC index by an average of 52%, but there was no significant decrease in the hepatic clearance of vardenafil. The frequency of negative side effects of the drug does not depend on age. In individuals with mild, moderate and severe renal insufficiency (creatinine clearance, respectively, 55-80, 30-50 and ≤ 30 ml / min), the pharmacokinetics of vardenafil practically does not change. In patients with minor and moderate hepatic impairment, the clearance of vardenafil decreases, and the AUC and maximum concentration values increase in proportion to the degree of hepatic impairment.

Indications

Erectile dysfunction (inability to achieve and maintain an erection necessary for sexual intercourse). Application inside regardless of the meal. The recommended starting dose is 10 mg. The tablet should be taken 15-25 minutes before the start of sexual contact, but it can be taken 4-5 hours. To achieve the desired effect when applying Levitra needs adequate sexual stimulation. Taking into account the effectiveness and tolerability of the drug, the dose can be increased to 20 mg or reduced to 5 mg. Maximum recommended dose Levitra — 20 mg, the frequency of administration – no more than 1 time per day. There is no need to adjust the dosage regimen in the elderly, patients with renal insufficiency or minor liver dysfunction. In patients with moderate hepatic impairment, the clearance of vardenafil is reduced, so the initial dose of the drug should not exceed 5 mg / day. Taking into account the effectiveness and tolerability in the future, the daily dose of Levitra can be increased to 10-20 mg.

49 reviews for Brand Levitra

  1. Olivia Cantu –

  2. Gabriel Guevara –

  3. Frank Wolfe –

  4. Austin Ahmed –

  5. Vincent Patrick –

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  45. Heather Matthews –

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  48. Christina Cortez –

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