Brand Premarin

(48 customer reviews)

Premarin is is a mixture of estrogen hormones used to treat menopause symptoms such as hot flashes, vaginal dryness, irritation and dryness, to prevent osteoporosis in postmenopausal women.

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Description

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Contraindications

Breast cancer and estrogen-dependent neoplasms; uterine bleeding of unclear etiology; thrombophlebitis, blood clotting disorders, thromboembolic diseases; severe diseases of the cardiovascular system; severe liver or kidney dysfunction; sickle cell anemia; congenital hearing loss; prolonged immobilization.

Use during pregnancy and lactation Contraindicated during pregnancy.

Side effects

Headache, nausea, vomiting, weight gain, edema, uterine bleeding, facial skin pigmentation, nodular erythema, transient increase in transaminase levels in blood plasma, hyperbilirubinemia; allergic reactions (rash); rarely – hemorrhagic skin rashes, endometrial neoplasms.

Special instructions

With caution in bronchial asthma, epilepsy, arterial hypertension.
During treatment, it is necessary to keep in mind the risk of developing endometrial cancer in postmenopausal women. Before taking it, a thorough general medical and gynecological examination should be carried out, including examination of the mammary glands and performing a vaginal Pap smear to detect malignant cells. Such studies should be carried out every 6 months of treatment. Patients with an intact uterus in order to reduce the risk of endometrial hyperplasia or cancer are prescribed in combination with progestogens from the 10th to the 14th day of the menstrual cycle. If gestagen therapy is not carried out, a gynecological examination with a mandatory endometrial biopsy is indicated.

Interaction

The effect is reduced by barbiturates, hydantoines, butadione, rifampicin.

How to take, course of administration and dosage

Inside. For cyclical use – 625 mcg – 1.25 mg per day, alternating intake for 3 weeks with a break of 1 week, with menstrual bleeding, the intake begins from the 5th day of the menstrual cycle, and from the 15th to the 21st day, a gestagenic drug is additionally used (with prolonged absence of menstruation, treatment begins any day). If necessary, on the 5th-7th day of treatment, the daily dose can be increased to 3.75 mg, then it is reduced to 1.25 mg. Treatment of malignant neoplasms – 3.75-7.5 mg.

48 reviews for Brand Premarin

  1. Gerald Diaz –

  2. Linda Parrish –

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  47. Albert Nguyen –

  48. Janice Fox –

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