Side effects of the substance Clonidine
From the nervous system and sensory organs: asthenia, drowsiness, slowing of the speed of mental and motor reactions, anxiety, nervousness, headache, dizziness, night anxiety, euphoria, sedative effect (more pronounced in the elderly), depression, vivid or nightmarish dreams. From the cardiovascular system and blood (hematopoiesis, hemostasis): bradycardia, orthostatic hypotension; with rapid intravenous administration – an increase in blood pressure (short-term). Allergic reactions: skin rash, itching. Other: Na+ and water retention, manifested by swelling of the feet and ankles; nasal congestion, decreased potency and/or libido, withdrawal syndrome, increased HELL, the so-called hemitonic crisis. Local reactions when using eye drops: conjunctival dryness, itching or burning in the eyes, feeling of a foreign body, hyperemia and swelling of the conjunctiva, conjunctivitis.
The hypotensive effect is weakened by tricyclic antidepressants. When used with neuroleptics, there is a mutual increase in sedative manifestations, pronounced depressive disorders may occur.
Symptoms: impaired consciousness, collapse, bradycardia, broadening of the QRS complex, possible slowing of AV conduction and early repolarization syndrome are characteristic of acute poisoning. Treatment: symptomatic.
Method of administration and dosage
Parenterally, sublingually, inside, instillation into the eye (drops). The doses and treatment regimen are individual.
In acute myocardial infarction, as well as for the treatment of vasomotor symptoms against the background of dysmenorrhea or menopause, withdrawal syndrome in drug addicts and labile hypertension, its appointment is especially undesirable. To prevent orthostatic hypotension during intravenous administration, the patient should be in a horizontal position during and for 1.5-2 hours after injection. When using eye drops, systemic side effects are possible; to reduce them after instillation, it is necessary to press the area of the lacrimal sac with your finger for 1-2 minutes. It should be borne in mind that clonidine in the form of eye drops can reduce systemic blood pressure. The development of a weakly positive Coombs reaction is possible. During the treatment period, it is necessary to be careful when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.