Description
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Pharmacological action
Antitumor agent of alkylating action, also has an immunosuppressive effect. It is an inactive transport form that decays under the action of phosphatases with the formation of an active component directly in tumor cells, “attacks” the nucleophilic centers of protein molecules, disrupts the synthesis of DNA and RNA, blocks mitotic division.
Side effects
Nausea, vomiting, toxic hepatitis; alopecia; abacterial hemorrhagic cystitis; leukopenia, thrombocytopenia; myalgia, ossalgia, headache.
Special instructions
During treatment, it is necessary to monitor the picture of peripheral blood: during the main course – 2 times a week, with maintenance therapy – 1 time a week. With a decrease in leukocytes to 2.5 thousand / ml and platelets – up to 100 thousand / ml, treatment should be discontinued. When used in higher doses for the prevention of hemorrhagic cystitis, it is advisable to prescribe uromitexan (mesna). It is necessary to consume more fluids during treatment. When using cyclophosphamide for the treatment of non-tumor diseases, extreme caution is recommended due to the possible carcinogenic effect of the drug with prolonged use.
Interaction
The drug may enhance the effect of hypoglycemic drugs. Simultaneous administration of allopurinol may lead to more pronounced myelodepression. Increases cardiotoxicity of adriamycin and rubromycin. The effect of cyclophosphamide is enhanced by chlorpromazine, tricyclic antidepressants, barbiturates, theophylline, hingamine, thyroid hormones, reduce (including toxic effect) – GCS, chloramphenicol.
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