Application
Endometriosis with concomitant infertility, benign breast neoplasms (including fibrocystic mastopathy), primary menorrhagia, premenstrual syndrome, primary premature puberty, gynecomastia. Prevention of all types (skin, abdominal, laryngeal) exacerbations in hereditary angioedema.
Contraindications
Hypersensitivity, porphyria (possibly exacerbation of the disease), breast cancer, androgen-dependent tumors, including prostate cancer, thromboembolism, genital bleeding (until their causes are clarified), moderate or severe renal and / or hepatic insufficiency, severe heart failure, pregnancy, breast-feeding. Restrictions on use Diabetes mellitus, epilepsy, migraine, violation of plasma mechanisms of hemostasis, old age.
Side effects
From the nervous system and sensory organs: dizziness, fainting, emotional lability, nervousness, muscle spasm, headache, increased intracranial pressure, lumbalgia, paresthesia, sleep disorders, vision disorders. From the gastrointestinal tract: nausea, liver dysfunction, reversible increase in liver transaminase activity, hepatitis, epigastric pain, cholestatic jaundice, hepatoadenoma. From the endocrine system: menstrual function disorders, including irregular menstrual periods, amenorrhea; symptoms indicating a decrease in estrogen levels — flushes of blood to the face, increased sweating, vaginal dryness, painful sensitivity and a decrease in the size of the mammary glands. Allergic reactions: urticaria, itching, exfoliative dermatitis; rarely – nasal congestion; sometimes – rash (maculopapular, vesicular, papular), petechiae.
Interaction
When used in combination with coumarin anticoagulants and indanedione derivatives, the effect of anticoagulants may increase (hepatic synthesis of procoagulant factors decreases, bleeding is possible). Danazol may increase blood glucose levels and insulin resistance due to changes in the metabolism of carbohydrates (it may be necessary to adjust the dose of hypoglycemic agents and insulin). When used with carbamazepine, carbamazepine metabolism may be suppressed, leading to increased blood concentrations and toxicity. Danazol may increase the concentration of cyclosporine and tacrolimus in the blood (risk of nephrotoxicity), glucagon.
Overdose
Symptoms: headache, dizziness, tremor, convulsions, nausea, vomiting. Treatment: gastric lavage, symptomatic therapy.
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