Description
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Dosage regimen
The initial daily dose is 150-200 mg (in 3 doses). In mild forms of depression, the average maintenance dose is 150 mg / day; in moderate and severe forms – 300 mg / day. If necessary, the dose can be increased to 600 mg / day. The main part of the daily dose is recommended to be taken before bedtime.
Side effect
From the central nervous system and peripheral nervous system: drowsiness, fatigue, dizziness, insomnia, headache, agitation, myalgia, impaired coordination of movements, paresthesia, disorientation, darkening of consciousness, tremor.
From the cardiovascular system: arrhythmia, conduction disorder, bradycardia, ventricular fibrillation, decreased blood pressure, orthostatic hypotension, fainting.
From the digestive system: nausea, vomiting, diarrhea, dryness and bitterness in the mouth.
From the side of the organ of vision: visual impairment, eye irritation.
From the hematopoiesis system: leukopenia, neutropenia (usually minor).
Other: nasal congestion, priapism followed by impotence, allergic reactions.
Contraindications to use
Ventricular arrhythmia, tachycardia, myocardial infarction (early recovery period), a history of priapism, pregnancy, lactation, hypersensitivity to trazodone.
Use during pregnancy and lactation
Use during pregnancy and lactation is contraindicated.
Use in cases of liver dysfunction
Use with caution in hepatic insufficiency.
Use in cases of impaired renal function
Use with caution in case of renal insufficiency
Indications
Various forms of depression (endogenous, psychotic, neurotic, somatogenic), including those with severe anxiety, including at least 4 of the following signs: sleep disorders, appetite, psychomotor agitation or inhibition, decreased interest in the environment, decreased sexual activity, guilt, increased fatigue, slow thinking, decreased ability to concentrate, suicidal attempts /thoughts; bulimia, kleptomania, anxiety, phobias. Benzodiazepine drug dependence; acute alcohol withdrawal syndrome. Decreased libido, impotence. Prevention of migraine attacks.
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