(26 customer reviews)

Differin helps to clear the acne and helps to keep new acne from starting.

SKU: Differin Categories: ,
Where to buy Differin online?


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Adapalene is a retinoid metabolite that acts on the pathological mechanism of development Acne vulgaris, is a strong modulator of cellular differentiation and keratinization and has comedonolytic and anti-inflammatory activity. The mechanism of action of adapalene is based on interaction with specific gamma receptors of epidermal skin cells. As a result of the action of adapalene, there is a decrease in the “cohesion” of epithelial cells at the mouth of the sebaceous hair follicle and a decrease in the formation of microcomedones. Adapalene has an anti-inflammatory effect in vivo and in vitro, acting on inflammatory factors by inhibiting the migration of leukocytes in the focus of inflammation, inhibits the chemotactic and chemokinetic responses of human polymorphonuclear leukocytes and suppresses the metabolism of arachidonic acid to inflammatory mediators, AP-1 factors and the expression of Toll-like receptors 2.

Special instructions

Avoid getting gel or cream in the eyes, on the lips and on the mucous membranes. In case of accidental contact of the drug on the mucous membranes of the eyes, mouth or nose, rinse them thoroughly with warm water. Avoid direct sunlight, as slight skin irritation may occur. Treatment can be continued if the sun exposure is minimized (the use of sunglasses and hats). Simultaneous use of cosmetics with a drying or irritating effect on the skin (for example, perfumes or alcohol-containing products) is not recommended. Adapalene applied to the skin in the evening can be combined with acne medications used in the morning.

26 reviews for Differin

  1. Billy Ortega

  2. Emma Boone

  3. Harold Moon

  4. Vincent Eaton

  5. Robert Sexton

  6. Victoria Cherry

  7. Philip Person

  8. Vincent McKinney

  9. Eric Pacheco

  10. Jacqueline Montgomery

  11. Kathleen Rasmussen

  12. Juan Shah

  13. Kenneth Gordon

  14. Christine Branch

  15. Jeffrey Chang

  16. Nancy Wheeler

  17. Helen Wood

  18. Dylan Alvarado

  19. Joshua Velez

  20. Marilyn Juarez

  21. Terry Lawson

  22. Barbara Harmon

  23. Samuel Mitchell

  24. Dylan Hawkins

  25. Cheryl Wilson

  26. Lawrence Compton

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