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Use during pregnancy and lactation
Pregnancy should be avoided for at least 1 month after discontinuation of treatment with Dostinex, since it is characterized by a long half-life, and in addition, there are only limited data on the effect of the drug on the fetus, although the use of Dostinex 0.5-2 mg per week in diseases associated with hyperprolactinemia is not accompanied by an increased risk of miscarriage, premature birth, various pregnancy anomalies and congenital malformations of the fetus.
Postpartum hypertension; preeclampsia; hypersensitivity.
From the SSS side: palpitations; rarely – orthostatic hypotension (with prolonged use of Dostinex® usually has a hypotensive effect); asymptomatic decrease is possible Blood pressure during the first 3-4 days after delivery (SAD – more than 20 mmHg, dAD – more than 10 mmHg). From the nervous system: dizziness/vertigo, headache, fatigue, drowsiness, depression, asthenia, paresthesia, fainting. From the digestive system: nausea, vomiting, epigastric pain, abdominal pain, constipation, gastritis, dyspepsia. Other: mastodynia, nosebleeds, flushes of blood to the skin of the face, transient hemianopsia, spasms of the vessels of the fingers and muscle cramps of the lower extremities (like other ergot derivatives, Dostinex® can have a vasoconstrictive effect).
Overdose symptoms may be similar to those that occur as a result of excessive stimulation of dopamine receptors (for example, nausea, vomiting, stomach disorders, postural hypotension, confusion/ psychosis or hallucinations). If necessary, supportive measures should be applied to remove any residues of the unabsorbed drug and maintain blood pressure. In addition, it may be advisable to administer drugs of the dopamine antagonist group.