Description
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Eldepril Selegiline is used as monotherapy at an early stage of the disease or in combination with levodopa drugs (in combination with or without peripheral decarboxylase inhibitors). In both cases, the initial dose is 5 mg, which is taken in the morning. The dose of Eldepril can be increased to 10 mg / day (can be taken in the morning or divided into two doses). If, when using the drug as an adjunct therapy to levodopa drugs, adverse reactions occur that are predetermined by levodopa, the dose of the latter should be reduced. Liver failure. There is no information about dose changes in patients with hepatic insufficiency. Kidney failure. There is no information about dosage changes in patients with renal insufficiency.
Contraindications
Hypersensitivity to selegiline or any of the excipients. Stomach and duodenal ulcer in the acute stage. Concomitant use with serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors (venlafaxine), tricyclic antidepressants, sympathomimetics, MAO inhibitors (linezolid) or opioids (pethidine) (see INTERACTIONS). When combining selegiline with levodopa, contraindications to the use of levodopa should be taken into account.
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