Description

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Side Effects

The occurrence and serious side effects are usually directly related to the concentration of lithium in the serum, as well as to the sensitivity to individual patients too lithium and usually occurs more often and with greater severity. higher concentrations.

Side effects may occur at serum lithium levels below 1.5 mEq/L. Minor to moderate side effects may occur at levels from 1.5 to 2.5 mEq/L, and moderate to severe reactions may occur at levels of 2.0 mEq/L and higher.

Fine hand stamping, polyuria and mild thirst may occur during the initial therapy of the acute manic phase and persist throughout the treatment. Temporary and mild nausea and general complaints may also occur in the first days of lithium administration.

These side effects usually go away with continued treatment or a temporary reduction or discontinuation of the dosage. If persistence is complete, lithium therapy may be required.

Diarrhea, vomiting, drowsiness, muscle weakness and lack of coordination may be early signs of lithium poisoning and occur at lithium levels below 2.0 mEq/L. At higher levels, ataxia, dizziness, tinnitus, blurred vision and a large amount of diluted urine may occur. . Serum lithium levels above 3.0 mEq/L can create a complex clinical image involving multiple organs and organ systems. The serum lithium level should not exceed 2.0 meq/l during the acute treatment phase.

The following reactions have been reported that appear to be associated with serum lithium levels, including levels in the therapeutic range:

Maximum.

Cardiovascular

Cardiac arrhythmias, Hypotension, Peripheral circulation Collapse, bradycardia, sinus node dysfunction with severe bradycardia (may lead to fainting).

Gastrointestinal tract

Anorexia, nausea, vomiting, diarrhea, gastritis, saliva Glandular tumor, abdominal pain, excessive salivation, flatulence, upset stomach.

Urogenital

Glycosuria, decreased creatinine clearance, albuminuria Oliguria and symptoms of nephrogenic diabetes insipidus, including polyuria, thirst and polydipsia.

Dermatological: Drying and thinning of hair, alopecia, anesthesia of the skin Acne, chronic folliculitis, xerosis, psoriasis or their exacerbation, generalized itching with or without rash, skin ulcers, angioedema.