Etodolac

(44 customer reviews)

Etodolac is used to treat pain or inflammation caused by arthritis or osteoarthritis.

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Description

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Pharmacological properties

It has anti-inflammatory, antipyretic and pronounced analgesic effect. The mechanism of action is associated with a violation of prostaglandin synthesis as a result of inhibition of COX activity. Indications are rheumatism, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, pain syndrome of various genesis.

Pregnancy and breastfeeding

Use in pregnancy, the category of action on the fetus according to the FDA – C. Adequate and strictly controlled clinical studies of the safety of the use of etodolac during pregnancy have not been conducted. The use of nonsteroidal anti-inflammatory drugs can lead to premature closure of the botall duct in the fetus and, possibly, to prolonged pulmonary hypertension in the newborn, delayed onset of labor and increased duration of labor. Regular use of nonsteroidal anti-inflammatory drugs in the third trimester of pregnancy can lead to a decrease in tone and weaker contractions of the uterus. Etodolac is contraindicated during pregnancy. Use during breastfeeding Special studies on the safety of the use of etodolac during breastfeeding have not been conducted. It is not known whether this drug penetrates into the mother’s milk. The risk to an infant cannot be excluded. Breastfeeding should be stopped for the duration of treatment.

Interaction

Concomitant use with other nonsteroidal anti-inflammatory drugs or glucocorticosteroids increases the risk of side effects. Etodolac binds to a high degree to plasma proteins, with simultaneous use with other drugs that also bind to plasma proteins (for example, anticoagulants), it is possible to enhance the effects of both active substances (dose adjustment is required). Etodolac enhances the effects of oral anticoagulants (fenindione) and heparin. Etodolac enhances the antiplatelet properties of ticlopidine (with their simultaneous use, it is necessary to control the duration of bleeding). Etodolac may enhance the hypoglycemic effect of sulfonamides. Etodolac increases the concentration of lithium in the blood plasma (with simultaneous use, it is necessary to monitor the concentration of lithium in the blood). Etodolac enhances the hematological toxicity of methotrexate. With simultaneous use, this drug weakens the effect of diuretics. Myelotoxic agents enhance the manifestations of hematotoxicity of the drug.

44 reviews for Etodolac

  1. Amanda Barnett

  2. David Marshall

  3. Terry Harding

  4. Bobby Cisneros

  5. Madison Ahmed

  6. Natalie Curry

  7. Dennis Figueroa

  8. Rose Navarro

  9. Donna Benson

  10. Karen Leonard

  11. Doris Campos

  12. Maria Watts

  13. Christine Potts

  14. Madison Humphrey

  15. Helen Allen

  16. Danielle Hinton

  17. Olivia McDonald

  18. Cheryl Cross

  19. William Wallace

  20. Emily Osborne

  21. Megan Curry

  22. Ethan Daugherty

  23. Carl Ramsey

  24. Raymond Walter

  25. Danielle Harrell

  26. Timothy Martinez

  27. Tyler Black

  28. Tyler Moore

  29. Nathan Shah

  30. Madison Cervantes

  31. Dennis Steele

  32. David Pacheco

  33. James Underwood

  34. Carolyn Waters

  35. Brandon Barajas

  36. Benjamin Vaughan

  37. Benjamin Cabrera

  38. Timothy Young

  39. Kayla Browning

  40. Natalie Barajas

  41. Charlotte Peck

  42. Kenneth Case

  43. Catherine Bradley

  44. Danielle Velasquez

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