(24 customer reviews)

Eulexin is used to treat a prostate cancer.

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Interaction with other drugs

The interaction of flutamide with leuprolide was not observed. If flutamide and LHRH agonists are used simultaneously, the potential harmful effect of both drugs should be considered. In patients receiving long-term warfarin therapy, there was an increase in prothrombin time after the use of flutamide. Therefore, it is necessary to select the optimal dose of anticoagulant. With the combined use of Flutamide and theophylline, it is possible to increase the concentrations of theophylline in blood plasma. Simultaneous use of Flutamide and potentially hepatotoxic drugs should be avoided. With simultaneous use, there is a possibility of interaction with paracetamol and opioid analgesics. Flutamide may slow down the metabolism of corticosteroids. Alcohol should not be consumed during treatment. Since the treatment of androgen deprivation can prolong the QT interval, the simultaneous use of Flutamide with drugs that prolong the QT interval, or drugs that can cause fluttering / flickering, such as Class IA (quinidine, disopyramide) or class III (amiodarone, sotalol, dofetilide, ibutilide) antiarrhythmic drugs, methadone, moxifloxacin, neuroleptics, etc., should be carefully appreciated.

Features of use

As part of combination therapy with LHRH agonists, Flutamide therapy should be started at least 3 days before the appointment of LHRH agonists, which contributes to less pronounced inflammatory hyperemia than in the case of parallel initiation of therapy. Treatment should be carried out under the supervision of a doctor. In case of liver dysfunction, long-term use of flutamide is possible only after a thorough assessment of the possible benefits and risks. Liver function should be checked before starting treatment. Treatment with the drug should not be started in patients with serum transaminase levels that are 2-3 times higher than the upper limit of the norm. Liver function should be checked during the entire treatment period, especially in patients who have not had an orchiectomy, since adverse reactions such as cholestatic jaundice, liver necrosis, changes in transaminase levels and hepatic encephalopathy have been noted. Appropriate laboratory testing should be carried out monthly during the first 4 months of treatment and then periodically, and at the first symptoms / signs of liver dysfunction (itching, dark urine, persistent lack of appetite, jaundice, moderate soreness in the upper right quadrant of the abdomen or general weakness). With laboratory confirmation of liver dysfunction or jaundice in the absence of liver metastases confirmed by biopsy, treatment should be discontinued if the patient continues to develop jaundice or if serum transaminase levels have exceeded the upper limit of normal by 2-3 times, even in the absence of clinical symptoms. Liver dysfunction is usually reversible after discontinuation of treatment with Flutamide. However, there is evidence of deaths due to severe liver damage caused by the use of flutamide.

24 reviews for Eulexin

  1. Logan Bonilla

  2. Virginia Mejia

  3. Gary Alfaro

  4. Cheryl Knox

  5. Jessica Randolph

  6. Jessica Acosta

  7. Willie Pena

  8. Amber Grant

  9. Juan Cortes

  10. Susan Felix

  11. Brandon Stafford

  12. Kathryn Robertson

  13. Linda Flynn

  14. Jose Houston

  15. Hannah Lara

  16. Frances Montes

  17. Laura Lugo

  18. Alexis Espinosa

  19. Virginia Underwood

  20. Carl Sierra

  21. Mary Shepard

  22. Pamela Lester

  23. Patrick Randolph

  24. Roy Schmitt

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