Description
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How to use: dosage and course of treatment
Inside, in / m, rectally, externally. Inside. For rheumatoid arthritis, osteoarthritis and ankylosing spondylitis – 10-30 mg / day in 1 dose, for a long time. In acute diseases of skeletal muscles – 40 mg / day for one or more doses for 2 days, in the next 7-10 days – 20 mg / day. In the treatment of acute gout, the initial dose is 40 mg, once, for the first 2 days, then for 4-6 days – 40 mg 1 time or 20 mg 2 times a day. With dysalgomenorrhea, treatment should begin when the first symptoms appear at an initial dose of 40 mg / day in 1 or several doses for 2 days. In the next 1-3 days – 20 mg in 1 dose. As an antipyretic drug – 10-20 mg / day; if necessary, a rapid effect is achieved – 40 mg / day is prescribed for the first 2 days, followed by a dose reduction. With juvenile rheumatoid arthritis, it is prescribed 1 time a day: for children with a body weight of less than 15 kg – 5 mg / day, 16-25 kg – 10 mg / day, 26-45 kg – 15 mg / day, more than 46 kg – 20 mg / day. In/m. For the treatment of acute conditions or relief of exacerbation of the chronic process – 20-40 mg 1 time per day. After the acute stage of the process is stopped, they switch to maintenance therapy with tablets or capsules. Rectally, 10-40 mg 1-2 times a day. Externally, a gel or cream is applied to the affected areas (5-10 mm column) 3-4 times a day; an occlusive dressing is not applied. advertisement Pharmacological action NSAIDs have anti-inflammatory, analgesic, antiplatelet and antipyretic effects. Nonselectively suppresses COX1 and COX2. The analgesic effect is manifested 30 minutes after oral administration, the anti-inflammatory effect occurs by the end of 1 week of treatment. After a single dose, the effect persists for 24 hours.
Side effects
From the nervous system: dizziness, headache, drowsiness, insomnia, depression, irritability, hallucinations, paresthesia, lethargy, mood changes. From the urinary system: impaired renal function, interstitial nephritis, papillary necrosis, nephrotic syndrome. From the digestive system: nausea, decreased appetite, abdominal pain, flatulence, constipation or diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, bleeding and perforation of the gastrointestinal tract; liver dysfunction, increased activity of “hepatic” transaminases; dry mouth, stomatitis. From the hematopoietic organs and hemostatic system: anemia, aplastic anemia, hemolytic anemia, leukopenia, eosinophilia, thrombocytopenia, decreased hematocrit; atrombocytopenic purpura (Schenlein-Henoch disease). From the side of the CCC: increased blood pressure, decreased blood pressure, rarely – palpitations, shortness of breath. Other: swelling of the legs and feet, increased sweating, increased urea concentration; hypoglycemia. Allergic reactions: skin rash, itching, swelling of the face, larynx, bronchospasm, malignant exudative erythema (Stevens-Johnson syndrome), shock, photosensitization; vasculitis, serum sickness. Local reactions: when using candles – irritation of the mucous membrane of the rectum, burning, tenesmus. With intravenous administration – the formation of aseptic necrosis, necrosis of adipose tissue.
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