Description

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Warnings

Nitrofurantoin is not effective for the treatment of parenchymal infections of unilaterally non-functioning kidneys. The surgical cause of the infection should be excluded in recurrent or severe cases.

Nitrofurantoin can be used with caution as a short-course therapy only for the treatment of uncomplicated lower urinary tract infection in some cases with eGFR from 30 to 44 ml/min for the treatment of resistant pathogens, when the benefits are expected to outweigh the risks.

Since pre-existing conditions can mask adverse reactions, nitrofurantoin should be used with caution in patients with pulmonary disease, hepatic dysfunction, neurological disorders and allergic diathesis.

Peripheral neuropathy and susceptibility to peripheral neuropathy, which can become severe or irreversible, has arisen and can be life-threatening. Therefore, treatment should be discontinued at the first signs of a neural lesion (paranesthesia).

Nitrofurantoin should be used with caution in patients with anemia, diabetes mellitus, electrolyte imbalance, debilitating conditions and vitamin B deficiency (especially folate).

Acute, subacute and chronic pulmonary reactions were observed in patients receiving nitrofurantoin. If these reactions occur, nitrofurantoin should be discontinued immediately.

Chronic pulmonary reactions (including pulmonary fibrosis and diffuse interstitial pneumonitis) can develop insidiously and can often occur in elderly patients. Careful monitoring of the pulmonary conditions of patients receiving long-term therapy is justified (especially in the elderly).

Patients should be carefully monitored for signs of hepatitis (especially with prolonged use).

Urine may be colored yellow or brown after taking nitrofurantoin. Patients receiving nitrofurantoin are susceptible to false positive glucose in the urine (if tested for reducing substances).

Nitrofurantoin should be discontinued at any signs of hemolysis in persons with suspected glucose-6-phosphate dehydrogenase deficiency.

Gastrointestinal reactions can be minimized by taking the drug with food or milk or by adjusting the dosage.

Discontinue treatment with nitrofurantoin if otherwise unexplained pulmonary, hepatic, hematological or neurological syndromes occur.