Description
Looking for a drugstore where you can buy Glucotrol Xl online? You can click on the button and go to the pharmacy with the cheepest prices. Anonymous delivery, quality drugs, absolutely confidentiality. Go to an online drugstore and choose the appropriate Glucotrol Xl dosage, and then the required amount of tablets. The buying process will be as secure and safe as possible. You can also buy Glucotrol Xl with fast delivery at the pharmacy, the drug will be delivered tomorrow. The getting is made without a prescription because we trust you and understand that you already know which medicine you need.
Indications
Insulin-dependent diabetes mellitus (with excess or normal body weight).
Contraindications
Hypersensitivity, insulin-dependent diabetes mellitus (juvenile diabetes, diabetes accompanied by ketoacidosis or precoma); severe renal or hepatic insufficiency; digestive tract stenosis; childhood.
Use during pregnancy and lactation
Contraindicated during pregnancy. It should be prescribed with caution to nursing women (hypoglycemia in newborns is possible).
Side effects
Hypoglycemia; nausea, diarrhea, discomfort in the epigastric region; cholestatic jaundice, toxic hepatitis; leukopenia, agranulocytosis, thrombocytopenia, hemolytic or aplastic.
Pharmacokinetics
It is absorbed quite fully. 2-3 hours after administration, it is determined in plasma at a significant concentration, which, gradually increasing, reaches a maximum after 6-12 hours. Taking 1 time a day maintains an effective level for 24 hours. Bioavailability — 90%. In the blood, it binds to proteins by 99%. Stable plasma concentrations are achieved on the 5th day of use (in patients over 65 years of age — 1-2 days later). The pharmacokinetics of glipizide is linear in the dose range of 5-60 mg. It is eliminated by biotransformation in the liver, only less than 10% of the administered dose is excreted unchanged in urine and feces; biotransformation products are also excreted in urine (80%) and feces (10%).
Overdose
The effect is enhanced by miconazole, phenylbutazone, alcohol, beta—blockers, ACE inhibitors (captopril, enalapril), acetylsalicylic acid (in large doses), sulfonamides, reduced by danazole, chlorpromazine (100 mg / day), glucocorticosteroids and tetracosactide (including topical application), progestogens, ritodrin, salbutamol, terbutalin (parenterally).
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