Description
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The use of Glucovance
Inside. Only for use in adults. Like the doses of other hypoglycemic agents, the dose of Glucovans is determined individually depending on the individual metabolic reaction (glycemic level and HbA1c). Adult patients with normal renal function (GFR ≥90 ml/min). When replacing combination therapy with metformin and glibeclamide, treatment with Glucovans is started at a dose corresponding to the previous level of doses received. The dose is gradually increased depending on the level of glycemia. Every ≥ 2 weeks after the start of therapy, it is necessary to adjust the dose of the drug (increase the dose by 1 tablet) depending on the level of glycemia. A gradual increase in the dose helps to reduce the severity of side effects from the gastrointestinal tract and prevents the development of hypoglycemia. Glucovance 500 mg/2.5 mg. The maximum recommended dose is 6 tablets of Glucovans 500 mg / 2.5 mg. There are no data on the combined therapy with Glucovans with insulin. The dosage regimen is set individually depending on the indications: 1 time per day: 1 tablet per day during breakfast; 2 times a day: 2 or 4 tablets a day in the morning and evening; 3 times a day: 3.5 or 6 tablets a day in the morning, afternoon and evening. Glucovance 500 mg/5 mg. The use of Glucovans 500 mg / 5 mg is recommended for patients who do not have adequate control of glycemia when taking lower doses. The maximum recommended dose is 3 tablets of Glucovans 500 mg / 5 mg. In individual cases, the dose can be increased to 4 tablets of Glucovans 500 mg / 5 mg. There are no data on the combined therapy with Glucovans with insulin. The dosage regimen is set individually depending on the indications: 1 time a day: 1 tablet a day during breakfast; 2 times a day: 2 or 4 tablets a day in the morning and evening; 3 times a day: 3 tablets a day in the morning, afternoon and evening. Tablets should be taken during meals. It is possible to adjust the dosage regimen in accordance with the individual diet. However, to prevent the occurrence of hypoglycemic episodes, it is necessary to eat food enriched with carbohydrates after each dose of the drug. In the case of combined use with bile acid sequestrants, it is recommended to take Glucovans at least 4 hours before taking bile acid sequestrants to minimize the risk of decreased absorption. Kidney failure. GFR should be evaluated before starting treatment with drugs containing metformin and after starting treatment at least annually. Patients with an increased risk of further progression of renal insufficiency and elderly patients should be closely monitored for kidney function as often as possible, for example, every 3-6 months. The maximum daily dose of metformin is recommended to be distributed in 2-3 daily doses.
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