Grifulvin V

(44 customer reviews)

Grifulvin V is an antifungal medication which used to treat fungal infections of the skin, scalp, and nails.

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Description

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Dosage

Inside, during or after a meal with vegetable oil. With microsporia, children are prescribed at the rate of 21-22 mg per 1 kg of the patient’s body weight per day, adults – from 500 to 1000 mg (8 tables. per day). The drug is taken daily until the first negative test for mushrooms, then at the same dose every other day for 2 weeks and then 2 times a week for 2 weeks.

With trichophytosis (superficial and infiltrative-suppurative forms) and favus for children – at the rate of 18 mg / kg of body weight according to the same scheme as with microsporia.

With onychomycosis, trichophytosis and favus of the scalp, the daily dose for adults weighing up to 50 kg is 625 mg (5 tables). The maximum daily dose is 1 g (8 tables). The daily dose in children and adolescents is 16 mg / kg of body weight.

With onychomycosis, the drug is prescribed daily for the first month, every other day for the second month, then 2 times a week in the same daily dose until the nails are completely regrown. The total duration of treatment is at least 8 months.

Pharmacokinetics

Absorption is high. Cmax – 0.5-5 mg / l, Tmax after oral administration – 4-5 hours. The bond with plasma proteins is 80%. Selectively accumulates in the stratum corneum of the skin and its appendages, as well as in the liver, adipose tissue, skeletal muscles. A small amount is distributed in body fluids and tissues. Penetrates through the placenta. It is metabolized in the liver with the formation of inactive metabolites (6-methylgriseofulvin and glucuronide derivative). T1/2 – 24 hours. It is excreted by the kidneys (including 1% – unchanged) and through the intestine (36% – unchanged).

Absorption is high. Cmax – 0.5-5 mg / l, Tmax after oral administration – 4-5 hours. The bond with plasma proteins is 80%. Selectively accumulates in the stratum corneum of the skin and its appendages, as well as in the liver, adipose tissue, skeletal muscles. A small amount is distributed in body fluids and tissues. Penetrates through the placenta. It is metabolized in the liver with the formation of inactive metabolites (6-methylgrifulvin Va and glucuronide derivative). T1/2 – 24 hours. It is excreted by the kidneys (including 1% – unchanged) and through the intestine (36% – unchanged).

44 reviews for Grifulvin V

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  3. Charlotte Kirby –

  4. Laura Beasley –

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