Description
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Special instructions
Caution should be exercised in patients with severe renal impairment. It is not recommended to use hydroxycarbamide in patients with chickenpox (including recently transferred or after contact with the sick), herpes zoster and other acute infectious diseases. For elderly patients, it may be necessary to adjust the dosage regimen. When using hydroxycarbamide in patients with gout or nephrolithiasis, the risk of hyperuricemia increases. Combination with radiation therapy can lead to increased side effects that are associated with myelodepression and damage to the gastric mucosa. Erythema caused by radiation may increase. Nausea, vomiting, anorexia caused by combined use with radiation therapy may disappear as a result of temporary withdrawal of hydroxycarbamide. Before and during treatment, a complete blood picture should be determined, including a study of the bone marrow, as well as kidney and liver function. Repeat the blood test at least 1 time / week. With a decrease in the number of leukocytes less than 2500 / ml, and platelets less than 100,000 / ml, treatment should be discontinued until the normal values of these indicators are restored. Possible changes in ESR (more often an increase). With the development of anemia, it should be treated without interrupting the course of hydroxycarbamide, with the help of replacement transfusions of erythrocyte mass. There may be changes in biochemical parameters: an increase in the concentration of urea, creatinine, uric acid in the blood, an increase in the activity of hepatic transaminases. It is not recommended to vaccinate patients and their family members.
Drug interaction
It is possible to increase myelodepression in the case of previous therapy with cytotoxic drugs.
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