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“Starter packaging”: 1 tablet (white) contains 1 mg of terazosin hydrochloride and 1 tablet (orange) – 2 mg; in a blister pack of 14 pcs. (7 tablets of each dosage), in a box of 1 blister. 1 tablet (orange) — 2 mg; in a package of 28 pcs. 1 tablet (light brown) – 5 mg; in a package of 28 pcs. 1 tablet (green) – 10 mg; in a package of 28 pcs.
In patients with prostate adenoma, urination normalizes (blockade of alpha1-adrenoreceptors of the smooth muscles of the triangle and neck of the bladder, the proximal part of the urethra, prostate gland). Causes the expansion of resistive (arterial) vessels, reduces OPSS and blood pressure. Reduces pre- and post-loading on the heart. Unlike non-selective blockers of alpha1- and alpha2-adrenergic receptors, it does not cause pronounced tachycardia. It has some hypolipidemic activity.
It is rapidly and completely absorbed into the gastrointestinal tract. Cmax in blood plasma is reached after 1 h. It binds intensively to blood proteins. T1/ 2 – 12 h. It is metabolized in the liver. About 10% is excreted unchanged in the urine and 20% – through the intestine; the rest is excreted as metabolites.
Use during pregnancy
During pregnancy, it is possible if the benefit to the mother exceeds the potential risk to the fetus. The category of action on the fetus according to the FDA – C. Breastfeeding should be stopped for the duration of treatment.
Contraindications to use
Hypersensitivity. Side effects Asthenia, impaired visual clarity, nasal congestion, nausea, peripheral edema, tendency to increase body weight in patients; decrease in hematocrit, hemoglobin, leukocytes, total protein and albumin in the blood. Method of administration and dosage Inside. Arterial hypertension: start with the lowest dose (1 mg), then it is increased to 1-5 mg / day in 1-2 doses. The maximum daily dose is 20 mg. Prostate adenoma: first take 1-2 mg, then up to 5 mg (clinical effect is achieved). If treatment is discontinued, the dose is reduced gradually (over several days).
Tachycardia, hypotension, orthostatic collapse. Interactions with other drugs Enhances (mutually) the effect of other antihypertensive drugs (dosage should be adjusted). It is compatible with analgesic, anti-inflammatory and cardiovascular agents, corticosteroids, etc.