(36 customer reviews)

Imuran suppresses immune system to treat autoimmune disease and is used in organ transplantation.

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In combination with corticosteroids and / or other immunosuppressive drugs for the prevention of organ rejection reactions during kidney, heart, liver transplantation, as well as to reduce the need for corticosteroids during kidney transplantation. As monotherapy or in combination with corticosteroids and/ or other drugs (which may include dose reduction or withdrawal of corticosteroids) is used for such diseases: severe rheumatoid arthritis; systemic lupus erythematosus; dermatomyositis and polymyositis; autoimmune chronic active hepatitis; vulgar pemphigus; nodular periarteritis; autoimmune hemolytic anemia; chronic refractory idiopathic thrombocytopenic purpura; recurrent intermittent multiple sclerosis.


Imuran is contraindicated in patients with hypersensitivity to azathioprine and other components of the drug. Hypersensitivity to 6-mercaptopurine.

Side effects

Myelodepression (leukopenia, thrombocytopenia, anemia), megaloblastic erythropoiesis and macrocytosis, nausea, vomiting, anorexia, skin rash, arthralgia, myalgia, drug fever, cholestatic hepatitis, development of secondary infections; in transplant recipients — erosive ulcerative lesions and bleeding from the gastrointestinal tract, pancreatitis, necrosis and intestinal perforation, rarely – acute renal failure, hemolytic anemia, acute pulmonary diseases, meningeal reactions.


Enhances the effect of depolarizing muscle relaxants and weakens — non-depolarizing. Immunosuppression is potentiated by allopurinol, oxypurinol, and thiopurinol.

Method of administration and dosage

Inside. Adults and children. Use in organ transplantation: up to 5 mg / kg / day on the first day of therapy; maintenance dose – 1-4 mg / kg / day, depending on clinical indications and hematological tolerability. Even in the case of low doses, maintenance therapy with Imuran should be carried out indefinitely, since there is a risk of transplant rejection. Use in the recurrent form of multiple sclerosis: 2-3 mg / kg / day; to achieve the effect, a treatment duration of more than 1 year may be required. It is not always possible to control the progression of the disease after 2 years of therapy. Use in other diseases: the initial dose is 1-3 mg / kg / day and should be selected in this dose range depending on the clinical effect (which may not be obtained within weeks and months from the start of treatment) and changes in the blood formula. If the therapeutic effect is obtained, then it is necessary to reduce the maintenance dose to the minimum level at which the effect is maintained. If the clinical effect is not achieved within 3 months, then Imuran should be canceled. However, in inflammatory bowel diseases, treatment should be carried out for at least 12 months, and the therapeutic effect can be achieved after 3-4 months. The maintenance dose can range from less than 1 to 3 mg / kg / day, and is determined by the disease, as well as the individual response of the patient. The experience of using Imuran in elderly patients is limited. Although according to available data, the incidence of side effects in the elderly does not exceed that in other patients taking Imuran, they should use the minimum dosages of the recommended dose range. Special attention should be paid to monitoring hematological parameters, reducing the maintenance dose to the minimum allowable to preserve the therapeutic effect. In patients with renal and/or hepatic insufficiency, the minimum doses of the therapeutic range should be used.

36 reviews for Imuran

  1. Carl Schmitt

  2. Shirley Briggs

  3. Walter Enriquez

  4. John Patterson

  5. Sean Tucker

  6. Samuel Travis

  7. Charlotte Travis

  8. Cynthia Ayala

  9. Alexander Schaefer

  10. Ronald Fowler

  11. Terry Hobbs

  12. James Dickerson

  13. Frances Bullock

  14. Carl Potter

  15. Joe Tang

  16. Jennifer Hansen

  17. Alice Moss

  18. Ruth Hunter

  19. Brittany Carr

  20. Eric Boyd

  21. Beverly Parra

  22. Kathleen Sheppard

  23. Deborah Donaldson

  24. Gregory Dunlap

  25. Sean Truong

  26. Stephen Galindo

  27. Donald Franco

  28. Rachel Cervantes

  29. Shirley Hoover

  30. Benjamin Hanna

  31. Logan Frank

  32. Steven McLaughlin

  33. Emma Bowman

  34. Brian Lim

  35. Karen Morgan

  36. Stephen Lucero

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