Indometacin

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Description

Drug name: Indomethacin

Active substance: Indomethacin

Pharmacological effects: Indomethacin is a non-steriodal anti-inflammatory drug which exerts anti-inflammatory, analgesic and antipyretic effect which is achieved through non-selective inhibition of COX-1 and COX-2, which regulate the synthesis of prostaglandines.

Indications: Indomethacin is prescribed in treatment of:

  • Inflammatory and degenerative disease of the locomotor system: rheumathoid, psoriatic, juvenile chronic arthritis, arthritis caused by Paget's disease, neurologic amyotrophy, Bechterew's disease, gout arthritis, rheumatism
  • Pain syndrome of different genesis: headache, tooth ache, lumbago, neuralgia, myalgia, post-traumatic and post-surgical pain, bursitis, tendinitis.
  • Algomenorrhea
  • Bartter syndrome
  • Pericarditis
  • Inflammation of the small bowel
  • Adnexitis
  • Bottalo's duct nonclosure
  • Inflammatory disease o the ENT organs with expressed pain syndrome
  • Fever syndrome

Warnings and Precautions: The drugs should not be used in the following conditions:

  • Hypersensitivity to any components of the preparations.
  • Samter's triad
  • Gastrointestinal ulcers
  • Ulcerous colitis
  • Gastrointestinal bleeding
  • Inborn cardiac anomaly
  • Color vision disorder
  • Liver cirrhosis
  • Visual nerve disease
  • Bronchial asthma
  • Chronic heart failure
  • Edema
  • Arterial hypertension
  • Blood coagulation disorders
  • Liver failure
  • Chronic renal failure
  • Decreased hearing
  • Pathology of the vestibular apparatus
  • Pregnancy
  • Lactation period
  • Young age less then 14 years

Indomethacin should be sued with caution in:

  • Hyperbilirubinemia
  • Thrombocytopenia
  • Epilepsy
  • Parkinson's disease
  • Depression
  • Elderly age after 65 years

Consult your doctor for other possible unique contradictions that may arise in you case.

Side effects: Drugs may cause side-effects which in specific patients may manifest differently. In the following paragraph we want to underline the most serious and frequent side effect of Indomethacin  that  were identified by the drug manufacturers. The possibility of the adverse effect manifestation depends only on the individual and his specific traits. Indomethacin side effects include:

  • Gastrointestinal tract: NSAID's-gastropathy, abdominal pain, nausea, vomiting, heartburn, decreased appetite, diarrhea, liver disorders, gastrointestinal ulcers in long-term treatment
  • CNS: headache, dizziness, insomnia, anxiety, irritation, fatigability, somnolence, depression, peripheral neuropathy.
  • Sensory organs: changes of taste, loss of hearing, ear ringing, diplopia, blurred vision, cornea opacification, conjunctivitis
  • Cardiovascular system: tachyarrhythmia, edema syndrome, hypertension, aggravation of the chronic heart failure symptomatology
  • Urogenital system: renal dysfunction, proteinuria, hematuria, interstitial nephritis, nephrotic syndrome, papilla necrosis
  • Haemopoietic organs: mucous membrane bleeding, anemia, thrombocytopenia, agranulocytosis, leukopenia,
  • Allergic reactions
  • Other: aseptic meningitis, increased sweating, aplastic anemia, autoimmune hemolytic anemia.

For full information on any risks and adverse effects associated with Indomethacin, please consult your doctor, read the included leaflet or contact our customer support service.

Interactions: Before using Indomethacin please tell your doctor which drugs or supplements you are already taking including those bought without a prescription. Also check if any additional medicine which you will take during the course of Indomethacin therapy are safe in combination. Especially mention if you are taking the following groups of drugs:

  • Cardiac glycosides
  • Anti-metabolites
  • Epilepsy treatment
  • Other NSAID's
  • Ethanol
  • Glucocorticosteroids
  • Diabetes treatment
  • Diuretics
  • Anticoagulants
  • Thrombolytic agents
  • Gout treatment
  • Beta-blockers
  • Hormonal treatment
  • Antibiotics
  • Au preparations
  • Antacids
  • Antivirals

Patients information: Indomethacin is not to be shared with healthy individuals. It is strictly FORBIDDEN to use the drugs in treatment of any conditions unrelated to their indications. The product as well as utilized vials, syringes, needles if used during the  course of treatment should be kept out of reach of children and never reused. 

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