Description
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The use of Intagra
Adults. The recommended dose of Intagra IC is 50 mg, which is taken, if necessary, about 1 hour before sexual intercourse. Considering the efficacy and tolerability, the dose can be increased to 100 mg or reduced to 25 mg. The maximum recommended dose is 100 mg. The maximum recommended frequency of admission is 1 time per day. The effectiveness of the drug may manifest itself later when taken with food compared to taking on an empty stomach. Elderly patients. For elderly patients (≥65 years), no dose changes are required. Patients with renal insufficiency. In patients with mild to moderate renal insufficiency (creatinine clearance – 30-80 ml / min), the recommended dose is the same as indicated above in the subsection “Adults”. Since sildenafil clearance is reduced in patients with severe renal insufficiency (creatinine clearance <30 ml/min), a 25 mg dose should be considered. Depending on the effectiveness and tolerability of the drug, if necessary, the dose can be increased gradually to 50 and 100 mg. Patients with hepatic insufficiency. Since sildenafil clearance is reduced in patients with hepatic insufficiency (for example, cirrhosis), the possibility of using a dose of 25 mg should be considered. Depending on the effectiveness and tolerability of the drug, if necessary, the dose can be increased gradually to 50 and 100 mg. Patients using other medications. If patients simultaneously use CYP 3A4 inhibitors (see INTERACTIONS), the possibility of using an initial dose of 25 mg should be considered (with the exception of ritonavir, the use of which simultaneously with sildenafil is not recommended – see SPECIAL INSTRUCTIONS). In order to minimize the possible development of postural hypotension in patients taking alpha-adrenergic blockers, their condition should be stabilized with the help of alpha-adrenergic blockers before the use of sildenafil. It is also necessary to consider the possibility of using an initial dose of 25 mg (see SPECIAL INSTRUCTIONS, INTERACTIONS). Children. The drug is not indicated for use in persons under the age of 18.
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