Drug name: Ketonal®
Other names used:
Therapeutic actions: Ketoprofen belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of a chemical (prostaglandin) which the body produces in response to injury or certain diseases. This prostaglandin would otherwise go on to cause swelling, pain and inflammation. All the medicines in this group reduce inflammation caused by the body's own immune system and are effective pain killers.
Indications: Ketoprofen is a medication that has been licensed to treat several conditions. Some ketoprofen uses include:
- Pain relief, such as for pain following a medical procedure, from straining a muscle, or caused by inflammation in a tendon (tendonitis) or bursa (bursitis). It can also be used to treat mild to moderate pain, such as lower back pain, neck pain, or leg pain.
- Treatment of arthritis symptoms, including pain, stiffness, and swelling. Ketoprofen can be used to treat several different types of arthritis, including osteoarthritis and rheumatoid arthritis. Ketoprofen does not cure these types of arthritis.
- Treatment of painful menstrual periods.
Contraindications and cautions:
You should not take ketoprofen if:
- You are allergic to ketoprofen or any of the inactive components used to make this medicine. Your healthcare provider or pharmacist has a list of the inactive ingredients.
- You have an active bleeding condition, such as a stomach ulcer or bleeding within the head.
- You have an allergic reaction, hives, or asthma that is caused by aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs).
- You are having or have recently had coronary bypass graft surgery (often known as open heart surgery, bypass surgery, or just CABG).
- You are in the third trimester of pregnancy or are nursing.
Before taking ketoprofen, let your healthcare provider know if you have:
- Heart disease, including congestive heart failure
- High blood pressure (hypertension)
- Liver disease or liver failure
- Kidney disease or kidney failure
- Bleeding problems (or are taking a medicine that decreases the ability for blood to clot)
- Stomach ulcers, stomach bleeding, or a history of them
- Any allergies to medicines, including aspirin or other NSAID pain medicines.
Also, let your healthcare provider know if you:
- Are pregnant or thinking about becoming pregnant
- Are breastfeeding
- Drink alcohol frequently
- Are having or have recently had heart surgery.
Be sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Adverse effects: Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
- sores in the mouth
- difficulty falling asleep or staying asleep
- ringing in the ears
Some side effects may be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more ketoprofen until you speak to your doctor.
- changes in vision
- unexplained weight gain
- swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
- difficulty breathing or swallowing
- excessive tiredness
- unusual bleeding or bruising
- lack of energy
- loss of appetite
- upset stomach
- pain in the upper right part of the stomach
- flu-like symptoms
- yellowing of the skin or eyes
- pale skin
- fast heartbeat
- cloudy, discolored, or bloody urine
- back pain
- difficult or painful urination
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
Interactions: It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
Especially pay attention to the following drugs:
- Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil®, Motrin®), naproxen (Aleve®, Anaprox®, Naprosyn®, Naprelan®), diclofenac (Cataflam®, Voltaren®), indomethacin (Indocin®), oxaprozin (Daypro®), celecoxib (Celebrex®), etodolac (Lodine®, Lodine XL), meloxicam (Mobic®), and others
- Warfarin (Coumadin®, Jantoven®)
- Lithium (Eskalith®, Lithane®, Lithonate®, Lithotabs®)
- Diuretics, such as torsemide (Demadex®), furosemide (Lasix®), and hydrochlorothiazide
- Angiotensin-converting enzyme inhibitors (ACE inhibitors) such as lisinopril (Zestril®, Prinivil®), fosinopril (Monopril®), captopril (Capoten®), quinapril (Accupril®), benazepril (Lotensin®), enalapril (Vasotec®), and ramipril (Altace®)
- Methotrexate (Rheumatrex®, Trexall™)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Probenecid (Benemid®, Probalan®)
- Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others.
Several herbal and nutritional supplements can also interact with ketoprofen and may increase the risk of bleeding. Examples of these include, but are not limited to:
- Dong quai
- Ginkgo biloba
- St. John's wort
- Fish oil supplements.
Additional Information: DO NOT SHARE THIS MEDICINE with others. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT, as well as syringes and needles, if needed during treatment, out of the reach of children. Do not reuse needles, syringes, or other materials.