Levoxyl

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Description

Pharmacological effects:

Levoxyl is a synthetic levogyratory isomer of thyroxine. After partial transformation into triiodothyronine (in the liver and kidneys) and passage to the cells of the body, the drug affects the development and growth of tissues and on the metabolism. Levoxyl in small doses has anabolic effects on protein and fat metabolism. In medium doses, the drug stimulates the growth and development, increases the oxygen demand of tissues, stimulates the metabolism of proteins, fats and carbohydrates, increases the functional activity of the cardiovascular system and central nervous system. In high doses, levothyroxine inhibits production of thyrotropin-releasing hormone of hypothalamus and pituitary TSH. The therapeutic effect is observed in 7-12 days of the treatment. Clinical effect in hypothyroidism is manifested in 3-5 days. Basedow's disease is reduced or disappears within 3-6 months.

Indications:

  • hypothyroidism
  • euthyroid goiter
  • as a replacement therapy and for prevention of recurrent goiter after thyroid gland resection
  • thyroid cancer (after surgery)
  • toxic goiter: after reaching the euthyroid state with thyreostatics
  • as a diagnostic drug during the thyroid suppression test

Warnings and Precautions: The drugs should not be used in the following conditions:

  • Hypersensitivity to any components of the preparations.
  • untreated hyperthyroidism
  • acute myocardial infarction, acute myocarditis

Precautions:

  • atherosclerosis, angina, myocardial infarction in the history
  • hypertension
  • arrhythmia
  • diabetes mellitus
  • heavy long-existing hypothyroidism
  • malabsorption syndrome

Side effects: Drugs may cause side-effects which in specific patients may manifest differently. In the following paragraph we want to underline the most serious and frequent side effect of levothyroxine that were identified by the drug manufacturers. The possibility of the adverse effect manifestation depends only on the individual and his specific traits. Levoxyl side effects include:

  • Allergic reactions

For full information on any risks and adverse effects associated with levothyroxine, please consult your doctor, read the included leaflet or contact our customer support service.

Interactions: Before using Levoxyl please tell your doctor which drugs or supplements you are already taking including those bought without a prescription. Also check if any additional medicine which you will take during the course of levothyroxine therapy are safe in combination. Especially mention if you are taking the following groups of drugs:

  • Indirect anticoagulants
  • Tricyclic antidepressants
  • Insulin and oral hypoglycemic agents
  • Cardiac glycosides
  • Anabolic steroids
  • Asparaginase
  • Tamoxifen
  • Salicylates
  • Anticonvulsants
  • Diuretics in high doses
  • Drugs containing estrogens
  • Somatotropin
  • Antituberculosis drugs

Patients information: Levoxyl is not to be shared with healthy individuals. It is strictly FORBIDDEN to use the drugs in treatment of any conditions unrelated to their indications. The product as well as utilized vials, syringes, needles if used during the course of treatment should be kept out of reach of children and never reused.

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