Description

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Indications

depressive episodes of any severity;

panic disorder with or without agoraphobia;

social anxiety disorder (social phobia);

generalized anxiety disorder;

obsessive-compulsive disorder.

Depression, panic disorders (including agoraphobia).

depressive episodes of any severity;

panic disorders with/without agoraphobia;

obsessive-compulsive disorder.

depressive episodes of any severity;

panic disorder with or without agoraphobia;

social anxiety disorder (social phobia);

generalized anxiety disorder;

obsessive-compulsive disorder.

Side Effects

From the side of the organ of vision: infrequently – mydriasis (pupil dilation), visual disturbances.

On the part of the organ of hearing and labyrinthine disorders: infrequently – tinnitus (tinnitus).

From the SSS side: infrequently – tachycardia; rarely – bradycardia; frequency unknown – prolongation of the QT interval on the ECG, orthostatic hypotension.

From the respiratory system, chest and mediastinal organs: often – sinusitis, yawning; infrequently: nosebleed.

From the gastrointestinal tract: very often – nausea; often – diarrhea, constipation, vomiting, dryness of the oral mucosa; infrequently – gastrointestinal bleeding (including bleeding from the rectum).

From the liver and biliary tract: the frequency is unknown – hepatitis, increased activity of liver enzymes.

From the skin and subcutaneous tissues: often – increased sweating; infrequently – urticaria, alopecia, skin rash, itching; frequency unknown – ecchymosis, angioedema.

From the musculoskeletal and connective tissue: often – arthralgia, myalgia.

From the kidneys and urinary tract: the frequency is unknown – urinary retention.

From the genitals and breast: often – impotence, ejaculation disorder; infrequently menorrhagia, metrorrhagia; frequency unknown – galactorrhea, priapism.

General disorders and disorders at the injection site: often – weakness, hyperthermia; infrequently – edema.

In the post-registration period, cases of prolongation of the QT interval were noted, mainly in patients with pre-existing heart diseases. In double-blind placebo-controlled ECG studies in healthy volunteers, the change from the baseline QTc value (correction according to the Frederick formula) was 4.3 ms at a dose of 10 mg/day and 10.7 ms at 30 mg/day.

Epidemiological studies involving patients aged 50 years and older have shown the existence of an increased risk of bone fracture in patients taking SSRIs and tricyclic antidepressants. The mechanism of occurrence of this risk has not been established.

The cancellation of drugs of the SSRI / SSRI group (especially abrupt) often leads to the occurrence of withdrawal syndrome. The most common are dizziness, sensitivity disorders (including paresthesia and the sensation of current passing), sleep disorders (including insomnia and intense dreams), agitation or anxiety, nausea and / or vomiting, tremor, confusion, increased sweating, headache, diarrhea, palpitations, emotional instability, irritability, visual disorders. As a rule, these effects are mild or moderate and pass quickly, but in some patients they may manifest themselves in a more acute form and/or for a longer time. It is recommended to gradually cancel the drug by reducing its dose.