(24 customer reviews)

Atorvastatin is a statin, used as a cholesterol- and triglyceride- lowering drug.

SKU: Lipitor Category:
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Hypersensitivity to the components of the drug, active liver diseases (including active chronic hepatitis, chronic alcoholic hepatitis), increased activity of “hepatic” transaminases (more than 3 times) of unknown origin, liver failure (severity A and B on the Child-Pugh scale), pregnancy, lactation.

With caution

Severe electrolyte imbalance, endocrine and metabolic disorders, alcoholism, a history of liver disease, arterial hypotension, severe acute infections, uncontrolled seizures, extensive surgical interventions, trauma, childhood (efficacy and safety of use have not been established).

How to use

Dosage and course of treatment Inside, take at any time of the day, regardless of the meal. The initial dose is 10 mg 1 time per day. The dose should be changed at intervals of at least 4 weeks. The maximum daily dose is 80 mg in 1 dose. With primary hypercholesterolemia and combined (mixed) hyperlipidemia, 10 mg is prescribed 1 time a day. The effect of the treatment is manifested within 2 weeks, the maximum effect is observed within 4 weeks. With homozygous familial hypercholesterolemia, 80 mg is prescribed once a day (a decrease in LDL content by 18-45%). Before starting therapy, the patient should be prescribed a standard hypocholesterolemic diet, which he must follow during treatment. 

Pharmacological action

Hypolipidemic agent from the group of statins. Selective competitive inhibitor of HMG-CoA reductase, an enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A into mevalonic acid, which is a precursor of sterols, including cholesterol. TG and cholesterol in the liver are included in the composition of VLDL, enter the plasma and are transported to peripheral tissues. LDL is formed from VLDL during interaction with LDL receptors. Taking the drug reduces the levels of cholesterol and lipoproteins in plasma due to the inhibition of HMG-CoA reductase, cholesterol synthesis in the liver and an increase in the number of “hepatic” LDL receptors on the cell surface, which leads to increased capture and catabolism of LDL. Reduces the formation of LDL, causes a pronounced and persistent increase in the activity of LDL receptors. Reduces the level of LDL in patients with homozygous familial hypercholesterolemia, which usually does not respond to therapy with hypolipidemic drugs. Reduces the level of total cholesterol by 30-46%, LDL – by 41-61%, apolipoprotein B – by 34-50% and TG – by 14-33%; causes an increase in the level of HDL cholesterol (high density lipoproteins) and apolipoprotein A. Taking the drug Lipitor dose-dependently reduces the level of LDL in patients with homozygous hereditary hypercholesterolemia resistant to therapy with other lipid-lowering drugs. Treatment with Lipitor significantly reduces the risk of ischemic complications (including the development of death from myocardial infarction) by 16%, the risk of repeated hospitalization for angina accompanied by signs of myocardial ischemia – by 26%. Atorvastatin does not have carcinogenic and mutagenic effects.

24 reviews for Lipitor

  1. Tyler Bravo

  2. Rachel Bush

  3. Ryan Conley

  4. Jeffrey Rhodes

  5. Roy Park

  6. Ethan Everett

  7. Judith Fields

  8. Cynthia Baldwin

  9. Elijah Hartman

  10. Richard Pennington

  11. Diane McGuire

  12. Kayla Deleon

  13. Catherine Lindsey

  14. Kenneth Booth

  15. Janet Oneal

  16. Timothy Clements

  17. Michael Barrera

  18. Kimberly Ayers

  19. Roger Cherry

  20. Jeffrey Waters

  21. Zachary Sanford

  22. Olivia Mosley

  23. Brian Wilkerson

  24. Kelly Maxwell

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