(49 customer reviews)

Thioridazine is used to treat psychotic disorders such as schizophrenia. It changes the actions of chemicals in your brain.

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Mellaril® (thioridazine HCl) is indicated for the treatment of patients with schizophrenia who cannot adequately respond to treatment with other antipsychotic drugs. Due to the risk of significant, potentially life-threatening, proarrhythmic effects in the treatment of mellaril (thioridazine hcl), mellaril (thioridazine hcl) should be used only in patients who could not adequately respond to treatment with appropriate courses of other antipsychotic drugs, or due to insufficient efficacy or failure to achieve an effective dose due to unacceptable side effects from these drugs. Therefore, before starting treatment with mellaril (thioridazine HCL), it is strongly recommended to give the patient at least 2 trials, each of which is a different antipsychotic drug, at an adequate dose and for an adequate duration. However, the prescriber should be aware that Mellaril (thioridazine hcl) has not been systematically evaluated in controlled studies in patients with refractory schizophrenia, and its efficacy in such patients is unknown.


The use of Mellaril® (thioridazine HCl) in combination with other medications that are known to prolong the QTc interval should be avoided, and in patients with congenital long QT syndrome or a history of cardiac arrhythmias. Drugs with reduced activity of cytochrome P450 2D6 isozyme that inhibit this isozyme (e.g..fluoxetine and paroxetine) and some other drugs (e.g..fluvoxamine propranolol and pindolol) seem to significantly inhibit the metabolism of thioridazine. The resulting elevated levels of thioridazine are expected to increase the prolongation of the QTc interval associated with Mellaril (thioridazine hcl) and may increase the risk of serious, potentially fatal, cardiac arrhythmias, such as torsade de pointe-type arrhythmias. This increased risk may also be due to the additive effect of co-administration of Mellaril (thioridazine hcl) with other agents that prolong the QTc interval. Therefore, Mellaril (thioridazine hcl) is contraindicated for these drugs, as well as for patients who make up about 7% of the normal population, which is known to have a genetic defect that leads to a decrease in the activity level of P450 2D6. Like other phenothiazines, Mellaril (thioridazine hcl) is contraindicated in severe depression of the central nervous system or comatose states for any reason, including drug depression of the central nervous system. It should also be noted that hypertensive or hypotensive heart disease of the extreme degree is a contraindication when phenothiazine is administered.

49 reviews for Mellaril

  1. Anna Brennan

  2. Anna Brock

  3. Samuel Farrell

  4. Willie Felix

  5. Danielle Knox

  6. Samuel Parsons

  7. Ralph McFarland

  8. Ralph Bailey

  9. Joan Anderson

  10. Kayla Velez

  11. Kevin Cline

  12. Pamela Buckley

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  49. Patricia Walsh

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