Methotrexate

(48 customer reviews)

Methotrexate is an antimetabolite used to treat certain types of cancer.

SKU: Methotrexate Category:
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Description

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Side effects

Central and peripheral nervous system: fatigue, dizziness, aphasia, convulsions. Hematopoiesis system: anemia, thrombocytopenia, leukopenia. Digestive system: ulcerative stomatitis, anorexia, nausea, rarely – melena, diarrhea, pancreatitis, fatty liver dystrophy. Urinary system: hematuria, cystitis. Reproductive system: oligospermia, decreased libido, menstrual disorders, impotence. Allergic reactions.

Overdose

Simtoms: increased side effects. Treatment: administration of calcium folinate at a dose equal to or greater than the dose of methotrexate. Hemodialysis.

Interaction

An increase in toxic effects is noted when used simultaneously with nonsteroidal anti-inflammatory drugs, barbiturates, corticosteroids, sulfonamides, tetracyclines, paraaminohippuric and paraaminobenzoic acid, probenecid, chloramphenicol. The effectiveness decreases when taking folic acid and its derivatives. Methotrexate is blocked by asparaginase with simultaneous use. Reduces the absorption of the drug with simultaneous administration of neomycin. The combination with live viral vaccines leads to an intensification of the replication of the vaccine virus and an increase in the side effects of vaccination. Enhances the effect of coumarin and indandion anticoagulants. Incompatible with nitric oxide, as the development of severe myelosuppression is possible.
Special instructions: People of reproductive age are recommended to use reliable contraceptives during treatment with methotrexate and for three months after the end of therapy.

Indications

It is used for acute lymphocytic leukemia, skin cancer, trophoblastic disease, cancer of the renal pelvis and ureters, esophageal cancer, squamous cell carcinoma of the head and neck, penile cancer, medulloblastoma, rhinoblastoma, lymphogranulomatosis. It is used for the treatment of severe forms of psoriasis and rheumatoid arthritis. 

Contraindications

Leukopenia, thrombocytopenia, immunodeficiency conditions, severe liver and kidney dysfunction. Individual intolerance.
With caution: Ulcers of the oral cavity and gastrointestinal tract, gout, infectious diseases, childhood and old age.

48 reviews for Methotrexate

  1. Carolyn Maldonado –

  2. Judy Vincent –

  3. Jerry Hughes –

  4. Sarah Moyer –

  5. Amy Hardin –

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  42. Lawrence Daniel –

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  44. Stephen Bowman –

  45. Christine Bennett –

  46. Catherine Chung –

  47. Richard Coffey –

  48. Sarah Hutchinson –

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