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From the immune system: very rarely — allergic reactions, including anaphylaxis, anaphylactic shock, hypersensitivity. From the endocrine system: rarely – an increase in prolactin levels. Mental disorders: very rarely — nervousness, irritability, agitation, depression, anxiety, decreased or lack of libido. From the nervous system: very rarely – insomnia, dizziness, thirst, convulsions, lethargy, headache, drowsiness, akathisia, extrapyramidal disorders. From the cardiovascular system: very rarely – edema, palpitation sensation, violation of the frequency and rhythm of heart contractions, prolongation of the QT interval (frequency unknown) severe ventricular arrhythmias, ventricular arrhythmias of the torsade de pointes type, sudden death. From the digestive tract: rarely – gastrointestinal disorders, including abdominal pain, regurgitation, changes in appetite, nausea, heartburn, constipation; very rarely – dry mouth, short-term intestinal cramps, diarrhea. From the skin and subcutaneous tissues: very rarely – itching, rash; the frequency is unknown — urticaria, angioedema. From the reproductive system and mammary glands: rarely – galactorrhea, enlargement of the mammary glands/gynecomastia, sensitivity of the mammary glands, discharge from the mammary glands, amenorrhea, swelling of the mammary glands, pain in the mammary glands, lactation disorders, irregular menstrual cycle. From the musculoskeletal system and connective tissue: rarely – pain in the legs. From the urinary system: very rarely – urinary retention, dysuria, frequent urination. General disorders: rarely – asthenia. From the side of the organ of vision: the frequency is unknown – oculogyric crises. Other: conjunctivitis, stomatitis. Changes in laboratory parameters: very rarely – an increase in the level of AlAT, AsAT and HC; infrequently – a deviation from the norm of liver functional tests; rarely – an increase in the level of prolactin in the blood. Since the pituitary gland is outside the BBB, domperidone can cause an increase in prolactin levels. In isolated cases, such hyperprolactinemia can lead to neuroendocrine side effects, such as galactorrhea, gynecomastia and amenorrhea. During the period of post-marketing use of the drug, there were no differences in the safety profile of domperidone in adults and children, with the exception of extrapyramidal disorders and other phenomena (seizures, agitation) associated with the central nervous system, noted mainly in children.