Description
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Side effect
From the digestive system: there may be a feeling of heaviness in the epigastric region, loss of appetite, nausea (especially at the beginning of treatment), vomiting, diarrhea, pancreatitis, swelling of the gums, liver dysfunction. From the nervous system: headache, tremor, paresthesia, hyperesthesia, epileptic syndrome, lethargy, disorientation, arousal, sleep disturbance, impaired consciousness, visual disorders; rarely – edema of the optic nerve discs. From the cardiovascular system: increase in blood pressure. From the urinary system: renal dysfunction, nephropathy, interstitial fibrosis, hematuria. From the side of metabolism: hyperlipidemia, hyperuricemia, hyperkalemia, hypomagnesemia; rarely – hyperglycemia. From the endocrine system: hypertrichosis, reversible dysmenorrhea and amenorrhea. From the musculoskeletal system: rarely – muscle spasms, muscle weakness, myopathy. From the hematopoiesis system: minor anemia; rarely – thrombocytopenia. Allergic reactions: skin rash, respiratory distress syndrome; blood flushes to the skin of the face and upper torso, bronchospasm, decreased blood pressure, tachycardia; in severe cases, shock. The occurrence of allergic reactions may be due to the presence of polyoxyethylated castor oil in some dosage forms. Other: fatigue, edematous syndrome, weight gain, burning in the hands and feet. Lymphoproliferative diseases after transplantation: lymphoma, malignant skin diseases.
Contraindications to use
Uncontrolled arterial hypertension; malignant neoplasms and precancerous skin diseases; lactation period (breastfeeding); children under 1 year of age; children’s age (for the treatment of psoriasis and rheumatoid arthritis); hypersensitivity to the components of the drug (including polyoxyethylated castor oil). With caution hyperkalemia; hyperuricemia; liver diseases; Behcet’s disease with neurological manifestations; traumatic brain injury or brain diseases, epilepsy; viral diseases, including chickenpox (currently existing or recently transferred, including recent contact with a patient), shingles (due to the risk of generalization of the process); hypertension; alcoholism; elderly patients; children’s patients.
Denise Adams –
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