(47 customer reviews)

Pentasa is a medication to treat ulcerative colitis.

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Side Effect

The most common adverse reactions that were observed during clinical trials were diarrhea, nausea, abdominal pain, headache, vomiting and rash. Sometimes hypersensitivity reactions and drug fever are observed. After rectal administration, local reactions such as itching, rectal discomfort and urge to defecate are possible. It is possible to develop increased fatigue, paresthesia, methemoglobinemia. The frequency of side effects reported during clinical trials and during post-marketing follow-up is determined as follows: often (from ≥1% to <10%), rarely (from ≥0.01% to <0.1%), very rarely (from <0.01%), the frequency is unknown. From the blood and lymphatic system: very rarely – eosinophilia (as a component of an allergic reaction), anemia, aplastic anemia, leukopenia (including granulocytopenia and neutropenia), thrombocytopenia, agranulocytosis, pancytopenia. From the immune system: very rarely — pancolitis, drug fever, in some cases — hypersensitivity reactions. From the nervous system: often – headache, rarely – vestibular reactions, dizziness, very rarely — peripheral neuropathy, benign intracranial arterial hypertension (in adolescents in puberty). From the heart: rarely – myocarditis * and pericarditis*. From the respiratory system, chest organs and mediastinum: very rarely — allergic and fibrotic changes from the lungs (including shortness of breath, cough, bronchospasm, allergic alveolitis, pulmonary eosinophilia, interstitial lung disease, pulmonary infiltration, pneumonitis). From the gastrointestinal tract: often – diarrhea, abdominal pain, nausea, vomiting; rarely – elevated amylase levels, acute pancreatitis *, flatulence; very rarely – exacerbation of colitis symptoms. From the liver and biliary tract: very rarely — impaired liver function (including increased levels of liver enzymes, cholestasis, bilirubin), hepatotoxicity (including hepatitis*, cholestatic hepatitis, cirrhosis, liver failure). From the skin and subcutaneous tissue: often – rash (including urticaria, erythematous rash), rarely – photosensitization reactions, very rarely – reversible alopecia, Quincke’s edema. From the musculoskeletal system and connective tissue: very rarely — myalgia, arthralgia, reactions similar to lupus erythematosus. From the kidneys and urinary system: very rarely — impaired renal function (including interstitial nephritis* (acute and chronic), nephrotic syndrome, renal failure), urine discoloration, renal failure, which may disappear when the drug is discontinued. From the genital organs: very rarely — oligospermia (reversible). General disorders: in some cases — drug fever. *The mechanism of development of mesalazin-induced myo- and pericarditis, pancreatitis, nephritis and hepatitis is unknown, but its allergic origin is possible. It should be noted that some of these disorders can be explained by intestinal inflammation itself. 

Pregnancy and lactation

In the first trimester of pregnancy, use is possible only for strict indications. If the individual course of the disease allows, then in the last 2-4 weeks of pregnancy, mesalazine should be discontinued. If it is necessary to use during lactation, the issue of stopping breastfeeding should be resolved, due to the lack of sufficient clinical experience with the use of mesalazine in this category of patients. Contraindicated in children under 2 years of age. Use in children under 2 years of age is possible only if the intended benefit of therapy exceeds the potential risk to the child.

47 reviews for Pentasa

  1. Isabella Spencer

  2. Jack Bravo

  3. Vincent Brown

  4. Gary Hicks

  5. Andrew Richards

  6. Gregory Farley

  7. Willie Bell

  8. Jeffrey Harris

  9. Heather Moss

  10. Linda Short

  11. Julie McKenzie

  12. Peter Rich

  13. Patrick Kerr

  14. Anthony Rosales

  15. Natalie Adams

  16. Janet Calhoun

  17. Aaron Shelton

  18. Edward Gallegos

  19. Anthony McGee

  20. John Liu

  21. Marilyn Ramirez

  22. Jennifer Woodward

  23. Amanda Sweeney

  24. Andrea Burns

  25. Joyce Cox

  26. Jack Contreras

  27. Logan Salazar

  28. Russell English

  29. Adam Snow

  30. Donald Potts

  31. Samantha Correa

  32. Rose Carlson

  33. Jose Fox

  34. Michael Herman

  35. Cheryl Butler

  36. Laura Underwood

  37. Julia Luna

  38. Alexander Tran

  39. Ashley Strickland

  40. Patrick Hanson

  41. Benjamin Sellers

  42. Barbara Day

  43. Rose Trujillo

  44. Emma Carey

  45. Cynthia Williamson

  46. Alan Huff

  47. Grace Wagner

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