Description
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How to take?
Adults Procardia should begin with one loading dose of 60 mg, and then continue with 10 mg once a day. In patients with UA / NSTEMI, where coronary angiography is performed within 48 hours after admission, the loading dose should be prescribed only during PCI. Patients taking Procardia should also take ASA daily (75 to 325 mg). In patients with acute coronary syndrome (ACS) who are prescribed PCI, premature discontinuation of any antiplatelet, including Procardia, may lead to an increased risk of thrombosis, myocardial infarction or death due to the underlying disease of the patient. Treatment is recommended for up to 12 months if the cessation of procardia is not clinically indicated. Patients > 75 years old The use of procardia in patients over 75 years of age is usually not recommended. If, after a thorough individual assessment of the benefits / risks by the prescribing doctor, treatment is considered necessary in the age group of patients > 75 years, then after a load of 60 mg, a reduced maintenance dose of 5 mg should be prescribed. Patients over 75 years of age have greater sensitivity to bleeding and higher exposure to the active metabolite of prasugrel. Patients weighing <60 kg Procardia should be administered as a single loading dose of 60 mg, and then continued at a dose of 5 mg once a day. A maintenance dose of 10 mg is not recommended. This is due to increased exposure to the active metabolite of prasugrel and an increased risk of bleeding in patients with a body weight of <60 kg when taking a dose of 10 mg once a day compared with patients > 60 kg. Kidney failure Dose adjustment is not required for patients with renal insufficiency, including patients with end-stage renal insufficiency. Patients with renal insufficiency have limited therapeutic experience. Liver failure Dose adjustment is not required in subjects with mild to moderate hepatic insufficiency (Child Pugh Class A and B). Patients with mild to moderate hepatic dysfunction have limited therapeutic experience. Procardia is contraindicated in patients with severe hepatic insufficiency (Pew child class). Child population The safety and efficacy of procardia in children under 18 years of age have not been established. There is limited data on children with sickle cell anemia. Method of application For oral use. Procardia can be administered with or without food. The introduction of a loading dose of prasugrel 60 mg in a hungry state can provide the fastest onset of action. Do not crush or break the tablet.
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