(24 customer reviews)

Protonix decreases a ruining effect of stomach acid on mucous of esophagus and used to heal erosive esophagitis.

SKU: Protonix Category:
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Side Effect

From the gastrointestinal tract: diarrhea; rarely – dry mouth, increased appetite, nausea, belching, vomiting, flatulence, abdominal pain, constipation, increased transaminase activity, gastrointestinal carcinoma (an isolated case). From the nervous system and sensory organs: headache; rarely – asthenia, dizziness, drowsiness, insomnia; in some cases – nervousness, depression, tremor, paresthesia, photophobia, visual disturbances, tinnitus. From the genitourinary system: in isolated cases — hematuria, edema, impotence. From the skin: in isolated cases — alopecia, acne, exfoliative dermatitis. Allergic reactions: rarely – rash, urticaria, itching, angioedema. Other: rarely – hyperglycemia, myalgia; in isolated cases — fever, eosinophilia, hyperlipoproteinemia, hypercholesterolemia.


Hypersensitivity to pantoprazole, benzimidazole derivatives or other components of the drug. Simultaneous administration of atazanavir. Due to insufficient data, the use of pantoprazole for the treatment of children under 12 years of age is not recommended. With caution: pregnancy, lactation, liver failure.


To date, there have been no overdose phenomena as a result of the use of the drug pantoprazole. Doses up to 240 mg administered intravenously for 2 minutes were well tolerated. Since pantoprazole is largely bound to plasma proteins, it is poorly exposed to hemodialysis. In case of overdose with clinical signs of intoxication, in addition to symptomatic and supportive treatment, there are no separate therapeutic recommendations.


Malignant neoplasm of the stomach In the presence of any alarming symptom (for example, a significant decrease in body weight, repeated vomiting, dysphagia, vomiting blood, anemia, melena) and in the presence or suspicion of a stomach ulcer, a malignant neoplasm should be excluded, since treatment with pantoprazole can weaken symptoms and delay diagnosis. It is necessary to consider the need for additional examination while maintaining symptoms, despite adequate therapy. Co-administration with HIV protease inhibitors The combined use of pantoprazole with HIV protease inhibitors, the absorption of which depends on the acidity of the pH of the stomach, such as atazanavir, is not recommended due to a significant decrease in their bioavailability. Effect on the absorption of vitamin B12 In patients with Zollinger-Ellison syndrome and other pathological hypersecretory conditions requiring long-term therapy, pantoprazole, like all antisecretory agents, can reduce the absorption of vitamin B12 (cyanocobalamin) due to hypo- or achlorhydria. This should be taken into account in patients with reduced reserves of this vitamin or in the presence of risk factors to reduce its absorption during long-term therapy or in the presence of appropriate clinical symptoms.

24 reviews for Protonix

  1. Heather Velez

  2. Emma Roman

  3. Diana Armstrong

  4. Ann Matthews

  5. Andrew Boone

  6. Michael Camacho

  7. Sarah Mann

  8. Grace Cuevas

  9. Christian Castaneda

  10. Stephen Flynn

  11. Joshua Tanner

  12. Melissa Jenkins

  13. Katherine Macdonald

  14. Kayla Vaughan

  15. Stephen Dejesus

  16. Jennifer Grimes

  17. Marilyn Daniels

  18. Patrick Schultz

  19. Frances Duffy

  20. Bobby Gates

  21. Megan Berger

  22. Gregory Harper

  23. Billy Jefferson

  24. Emma Odom

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