Sinemet

(33 customer reviews)

Sinemet is formulated from two medications: carbidopa and levodopa. It is used relieve symptoms of Parkinson’s disease such as the muscle tremor, stiffness, and weakness.

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Description

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Contraindications

Hypersensitivity, angle-closure glaucoma, severe psychosis or psychoneurosis, melanoma and suspected skin diseases of unknown etiology, pregnancy, lactation, age up to 12 years.

With caution

Myocardial infarction with rhythm disorders (in the anamnesis), bronchial asthma, lung diseases, epileptic seizures (in the anamnesis), erosive and ulcerative lesions of the gastrointestinal tract, diabetes mellitus, etc. decompensated endocrine diseases, severe hepatic and/or renal insufficiency, CHF. How to use: dosage and course of treatment Inside, 1/4 tablet (250 mg / 25 mg) 2-3 times a day, then the dose is increased by 1/4 tablet every 2-3 days until optimal effect is achieved. Usually, the optimal effect is noted at a dose of 1-2 tablets (250 mg / 25 mg) per day. The maximum daily dose is 1.5 g of levodopa and 150 mg of carbidopa (6 tablets 250 mg / 25 mg).

Interaction with other medications

With the simultaneous use of levodopa with antacids, the risk of side effects increases. With the simultaneous use of levodopa with antipsychotic drugs (neuroleptics) derivatives of butyrophenone, diphenylbutylpiperidine, thioxanthene, phenothiazine, pyridoxine, it is possible to inhibit the antiparkinsonian effect. With the simultaneous use of levodopa with beta-adrenomimetics, cardiac arrhythmias are possible. With the simultaneous use of levodopa with MAO inhibitors (with the exception of MAO type B inhibitors), circulatory disorders are possible. This is due to the accumulation of dopamine and norepinephrine under the influence of levodopa, the inactivation of which slows down under the influence of MAO inhibitors. With the simultaneous use of levodopa with m-holinoblockers, it is possible to reduce the antiparkinsonian effect; with drugs for anesthesia, there is a risk of arrhythmia. Reducing the bioavailability of levodopa with the simultaneous use of tricyclic antidepressants. With the simultaneous use of levodopa with diazepam, closepine, methionine, clonidine, phenytoin, it is possible to reduce the antiparkinsonian effect. Simultaneous use of levodopa with lithium salts may increase the risk of dyskinesia and hallucinations. With the simultaneous use of levodopa with papaverine hydrochloride, reserpine, a significant decrease in antiparkinsonian action is possible; with suxamethonium, arrhythmias are possible; with tubocurarine, an increased risk of arterial hypotension. The combination of carbidopa with levodopa makes it possible to reduce the dose and severity of the side effects of the latter, especially nausea, vomiting, arrhythmias.

33 reviews for Sinemet

  1. Kimberly Pearson

  2. Willie Branch

  3. Teresa Fry

  4. Amber Martin

  5. Jesse Serrano

  6. Rebecca Armstrong

  7. Jeffrey Price

  8. Laura Sawyer

  9. Amy Kerr

  10. Ann Torres

  11. Keith Faulkner

  12. Abigail Mullins

  13. Steven Tran

  14. Diana Kemp

  15. Carl Pruitt

  16. Kenneth Walters

  17. Nicholas Roberts

  18. Christian Harrison

  19. Timothy Stewart

  20. Scott Sloan

  21. Johnny Pratt

  22. Jesse Quinn

  23. Sandra Dalton

  24. Brittany Estrada

  25. Sara Sellers

  26. Christopher Conner

  27. Henry Price

  28. Shirley Potts

  29. Alice Vu

  30. Keith Christensen

  31. Ruth Romero

  32. Vincent Richardson

  33. Bryan Lara

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