(33 customer reviews)

Sinequan is antidepressant used to treat symptoms of depression and anxiety caused by alcoholism, manic-depressive or psychiatric conditions.

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Depressive states accompanied by anxiety (in particular, with pre-aging, senile involutional, reactive and postpartum psychoses, with manic-depressive psychosis), neuroses, sleep disorders of neurotic genesis, mild delusional syndromes that occur in the treatment of chronic alcoholism.

Side Effect

Headache, dizziness, drowsiness or insomnia, confusion, disorientation, anxiety, excessive sedation, nausea, vomiting, constipation, dryness of the mucous membranes of the mouth and nose, tachycardia or bradycardia, muscle tremor, excessive sweating, skin rash, itching.

Drug Interactions

Drugs Metabolized by P450 2D6

The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase) is reduced in a subset of the Caucasian population (about 7–10% of Caucasians are so-called “poor metabolizers”); reliable estimates of the prevalence of reduced P450 2D6 isozyme activity among Asian, African and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration may be small, or quite large (8-fold increase in plasma AUC of the TCA).

In addition, certain drugs inhibit the activity of this isozyme and make normal metabolizers resemble poor metabolizers. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). While all the selective serotonin reuptake inhibitors (SSRIs), e.g., citalopram, escitalopram, fluoxetine, sertraline, and paroxetine, inhibit P450 2D6, they may vary in the extent of inhibition. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved. Nevertheless, caution is indicated in the co-administration of TCAs with any of the SSRIs and also in switching from one class to the other. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary).

33 reviews for Sinequan

  1. Wayne Velazquez

  2. Doris Pugh

  3. Douglas Abbott

  4. Stephanie Tucker

  5. Natalie Montgomery

  6. Jean Bean

  7. Louis Barrett

  8. Randy Hardy

  9. Patricia Hess

  10. Willie Gordon

  11. Gloria Daugherty

  12. Denise Jaramillo

  13. Samantha Porter

  14. Patrick Pacheco

  15. Gabriel Perez

  16. Heather Hobbs

  17. Ashley Carpenter

  18. Adam Gill

  19. Carl Bass

  20. Cheryl Cochran

  21. Matthew McBride

  22. Emily Newton

  23. Mary Wyatt

  24. Ryan Reed

  25. Edward Harrell

  26. Andrew Flynn

  27. William Kemp

  28. Melissa Woodward

  29. Brenda Yates

  30. Lauren Nunez

  31. Deborah Phelps

  32. Christian Nielsen

  33. Nathan Wall

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