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The method of application and dosage regimen of a particular drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.
For adults and children over 12 years of age with a body weight of more than 50 kg, the daily dose is 400 mg (1 time / day or 200 mg 2 times / day). The duration of the course of treatment is 7-10 days. With uncomplicated gonorrhea – 400 mg once.
Children under the age of 12 years – 8 mg / kg of body weight 1 time / day or 4 mg / kg every 12 hours.
For infections caused by Streptococcus pyogenes, the course of treatment should be at least 10 days.
In case of impaired renal function (with CC from 21 to 60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%.
With CC < 20 ml / min or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.
From the digestive system: dry mouth, anorexia, diarrhea, nausea, vomiting, abdominal pain, flatulence, transient increase in the activity of hepatic transaminases and alkaline phosphatase, hyperbilirubinemia, jaundice, gastrointestinal candidiasis, dysbiosis; rarely – stomatitis, glossitis, pseudomembranous enterocolitis.
From the hematopoiesis system: leukopenia, thrombocytopenia, neutropenia, hemolytic anemia.
From the Central nervous System: dizziness, headache.
From the urinary system: interstitial nephritis.
Allergic reactions: skin itching, urticaria, skin hyperemia, eosinophilia, fever.
Contraindications to use
Hypersensitivity to cephalosporins and penicillins.
Use during pregnancy and lactation
Use during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.
If necessary, breastfeeding should be discontinued during lactation.
Use in cases of impaired renal function
In case of impaired renal function (with CC from 21 to 60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%. With CC < 20 ml / min, the daily dose should be reduced by 2 times.