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The method of application and dosage regimen of a particular drug depend on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen. They are installed individually. The usual dose for adults is inside, at the beginning of treatment is 25-50 mg 1 time / day. If necessary, the dose is gradually increased. With impaired renal function, patients with CC 15-35 ml / min – 50 mg / day; with CC less than 15 ml / min – 50 mg every other day. Maximum dose: adults when ingested – 200 mg / day in 1 or 2 doses.
From the cardiovascular system: in some cases – bradycardia, arterial hypotension, AV conduction disorders, the appearance of symptoms of heart failure. From the digestive system: at the beginning of therapy, nausea, constipation, diarrhea, dry mouth are possible. From the nervous system: at the beginning of therapy, fatigue, dizziness, depression, mild headache, sleep disturbances, a feeling of cold and paresthesia in the extremities, a decrease in the patient’s reactivity are possible. From the side of the organ of vision: decreased secretion of lacrimal fluid, conjunctivitis. From the endocrine system: decreased potency, hypoglycemic conditions in patients with diabetes mellitus. From the respiratory system: in predisposed patients – the appearance of symptoms of bronchial obstruction. Allergic reactions: skin itching. Other: increased sweating, redness of the skin.
Contraindications to use
AV blockade of II and III degrees, sinoatrial blockade, SSS, bradycardia, (heart rate less than 40 beats /min), arterial hypotension (if used in myocardial infarction, systolic blood pressure less than 100 mmHg), cardiogenic shock, chronic heart failure of stage IIB-III, acute heart failure, Prinzmetal angina, lactation, simultaneous administration of MAO inhibitors, hypersensitivity to atenolol.
Use during pregnancy and lactation
Atenolol penetrates the placental barrier, therefore, use during pregnancy is possible only if the intended benefit to the mother exceeds the possible risk to the fetus. Atenolol is excreted in breast milk, therefore, if necessary, it is recommended to stop breastfeeding during lactation.