Description
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Application of Tricor
Tricor mg can be taken at any time of the day, regardless of food intake (see PHARMACOLOGICAL PROPERTIES. Pharmacokinetics). Tablets should be swallowed whole, washed down with a glass of water. Diet therapy started before prescribing the drug should be continued. During the treatment of hyperlipidemia, the effectiveness of therapy should be monitored by determining the level of lipids in the blood serum. If an adequate response to treatment is not achieved after several months (for example, 3 months), additional or other therapeutic measures should be considered. Adults. The recommended dose is 1 tablet containing 145 mg of fenofibrate, 1 time per day. Patients who take 1 capsule containing 200 mg of fenofibrate or 1 tablet containing 160 mg of fenofibrate can replace them with 1 tablet of Tricor 145 mg without additional dose adjustment. If the patient needs to use fenofibrate for 2 indications (hyperlipidemia and diabetic retinopathy), only 1 tablet of Tricor 145 mg / day should be prescribed. Elderly patients. Elderly patients who do not have renal insufficiency are recommended the usual dose for adults. Impaired renal function. Patients with impaired renal function should reduce the dose. In chronic kidney diseases of moderate severity (creatinine clearance — 30-60 ml / min), the use of fenofibrate at a dosage of 145 mg is not recommended. In patients with severe chronic kidney disease (creatinine clearance <30 ml / min), the use of fenofibrate is contraindicated. Impaired liver function. Tricor 145 mg is not recommended for use in patients with impaired liver function due to lack of data.
Side effect
From the blood and lymphatic system: rarely – a decrease in hemoglobin and leukocytes. From the immune system: rarely – hypersensitivity reactions. From the nervous system: infrequently – headache. From the side of the vessels: infrequently – thromboembolism (pulmonary embolism and deep vein thrombosis of the lower extremities). From the digestive system: often – abdominal pain, nausea, vomiting, diarrhea, flatulence, increased activity of hepatic transaminases; infrequently – pancreatitis, cholelithiasis; rarely – hepatitis. From the skin and subcutaneous tissues: rarely – alopecia, photosensitization reactions. Allergic reactions: infrequently – skin rash, itching, urticaria. From the musculoskeletal system: infrequently – muscle lesions, including diffuse myalgia, myositis, muscle spasm and muscle weakness. From the genitals: infrequently – erectile dysfunction. From the laboratory indicators: very often – an increase in the concentration of homocysteine in the blood; infrequently – an increase in the concentration of creatinine in the blood serum; rarely – an increase in the concentration of urea nitrogen in the blood serum.
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