(40 customer reviews)

Oxcarbazepine is an anticonvulsant used to control certain types of seizures. It is also used as a mood stabilizing drug.

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There are isolated reports of drug overdose. The maximum dose described in the reports was approximately 48,000 mg. Symptoms: Violations of the water-electrolyte balance: hyponatremia. From the side of the organ of vision: diplopia, miosis, blurred vision. From the digestive system: nausea, vomiting, hyperkinesia. General disorders and disorders at the injection site: fatigue. Laboratory and instrumental data: decrease in the frequency of respiratory movements, prolongation of the QTc interval. From the nervous system: drowsiness, dizziness, ataxia, nystagmus, tremor, coordination disorder, seizures, headache, coma, loss of consciousness, dyskinesia. Mental disorders: aggression, agitation, confusion. From the side of the vessels: reduction of blood pressure. From the respiratory system, chest and mediastinal organs:shortness of breath. Treatment. There is no specific antidote. Symptomatic and supportive treatment is carried out. It should be borne in mind that to reduce the absorption of oxcarbazepine, gastric lavage can be performed and activated charcoal intake is prescribed. It is necessary to monitor the vital functions of the body, paying special attention to violations of the water-electrolyte balance, cardiac conduction and disorders of the respiratory system.

Pregnancy and lactation

Experience of use during pregnancy is limited. Available reports indicate a possible association of oxcarbazepine intake during pregnancy with the development of birth defects (for example, cleft palate). In experimental studies with the use of oxcarbazepine in toxic doses, an increase in embryonic mortality, slowing and disruption of fetal development and growth was noted. If the patient plans to become pregnant or became pregnant during the use of oxcarbazepine, as well as if there is a question about the use of oxcarbazepine during pregnancy, it is necessary to carefully compare the expected benefits of therapy and the possible risk to the fetus, especially in the first trimester of pregnancy. During pregnancy, oxcarbazepine should be used at the minimum effective dose. With sufficient clinical efficacy in women of childbearing age, oxcarbazepine should be used as monotherapy. During pregnancy, effective antiepileptic treatment should not be interrupted, since the progression of the disease can have a negative effect on the mother and on the fetus. It is known that folic acid deficiency develops during pregnancy. Antiepileptic drugs can increase this deficiency, which is one of the possible causes of fetal development disorders, therefore, additional folic acid supplementation is recommended. When used during pregnancy, it should be borne in mind that physiological changes occurring in the pregnant woman’s body can lead to a gradual decrease in the concentration of the active metabolite in the blood plasma. To achieve maximum control of the symptoms of the disease, it is necessary to regularly evaluate the clinical effect of oxcarbazepine and determine the concentration of the metabolite in blood plasma. Determination of the concentration of MHP in blood plasma is also recommended to be carried out in the postpartum period, especially if the dose of oxcarbazepine was increased during pregnancy. There are reports that the use of antiepileptic drugs during pregnancy can lead to increased bleeding in newborns. As a precautionary measure, it is recommended to prescribe vitamin K1 in the last few weeks of pregnancy, as well as to newborns whose mothers received oxcarbazepine. Oxcarbazepine and MHP penetrate the placental barrier and are excreted in breast milk. The ratio of concentrations in milk and plasma was 0.5 for both substances. Since the effect of oxcarbazepine and IHL on newborns received with mother’s milk is unknown, oxcarbazepine should not be used during breastfeeding.

40 reviews for Trileptal

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