Description
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Dosage regimen
Verapamil is taken orally during or after a meal, washed down with a small amount of water. The dosage regimen and duration of treatment are set individually depending on the patient’s condition, severity, features of the course of the disease and the effectiveness of therapy. For the prevention of angina attacks, arrhythmia and in the treatment of hypertension, the drug is prescribed to adults at an initial dose of 40-80 mg 3-4 times / day. If necessary, increase the single dose to 120-160 mg. The maximum daily dose of the drug is 480 mg. In patients with severe liver dysfunction, the excretion of verapamil from the body is slow, so it is advisable to start treatment with minimal doses. The daily dose of the drug should not exceed 120 mg.
Side effect
From the cardiovascular system: redness of the face, pronounced bradycardia, AV block, arterial hypotension, the appearance of symptoms of heart failure when using the drug in high doses, especially in predisposed patients. From the digestive system: nausea, vomiting, constipation; in some cases, a transient increase in the activity of hepatic transaminases in blood plasma. From the Central nervous System: dizziness, headache, in rare cases – increased nervous excitability, lethargy, increased fatigue. Allergic reactions: skin rash, itching. Other: development of peripheral edema.
Contraindications to use
Pronounced bradycardia; chronic heart failure of stage IIB-III; cardiogenic shock (except caused by arrhythmia);sinotrial block;AV block of II and III degrees (excluding patients with an artificial pacemaker);sinus node weakness syndrome;Wolf-Parkinson-White syndrome; Morgan-Adams-Stokes syndrome;acute heart failure;simultaneous use of beta-blockers (IV);children under 18 years; hypersensitivity to the components of the drug. With caution, it is necessary to prescribe the drug to patients with grade I AV block, grade I and II chronic heart failure, arterial hypotension (systolic pressure below 100 mm Hg), bradycardia, severe liver dysfunction.
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