Vermox

(48 customer reviews)

It is used in treatment of infections caused by pinworm, whipworm, hookworm and roundworm.

SKU: Vermox Category:
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Description

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Pharmacokinetics

It is practically not absorbed in the intestine. After taking the drug at a dose of 100 mg twice a day for three consecutive days, the plasma concentration of mebendazole and its metabolite (2-amino derivative) does not exceed 0.03 mcg / ml and 0.09 mcg / ml, respectively. The bond with plasma proteins is 90%. It is unevenly distributed among organs, accumulates in adipose tissue, liver, larvae, helminths. In the liver, it is metabolized to a 2-amino derivative that does not have anthelmintic activity. The half-life. 2.5-5.5 h. More than 90% of the dose is removed through the intestine unchanged. The absorbed part (5-10%) is excreted by the kidneys.  

Pharmacodynamics

A broad-spectrum anthelmintic drug, most effective against Enterobius vermicularis, Trichuris trichiura, Ascaris Iumbricoides, Ancylostoma, duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus D. granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni. Causing irreversible disruption of glucose utilization, depletes glycogen reserves in helminth tissues, prevents the synthesis of cellular tubulin, and also inhibits the synthesis of adenosine triphosphate (ATP).  

Indications for use

Enterobiosis, ascariasis, ankylostomidosis, strongyloidosis, trichocephalosis, trichinosis, teniosis, echinococcosis, teniosis, both with monoinvasia and with mixed helminthiasis; echinococcosis (if surgical treatment is impossible).

Contraindications to use

Hypersensitivity to mebendazole, other components of the drug, ulcerative colitis, Crohn’s disease, liver failure, children under 3 years of age, pregnancy, lactation, lactose intolerance, lactase deficiency, glucose-galactose malabsorption; simultaneous administration with metronidazole, phenytoin, carbamazepine, ritonavir.

Interaction

Reduces the need for insulin in diabetic patients. Joint administration with lipophilic substances should be avoided. Cimetidine can increase the concentration in the blood, carbamazepine and other inducers of metabolism – lower the concentration of Vermox in the blood.

48 reviews for Vermox

  1. Cheryl Alvarado –

  2. Edward Fox –

  3. Helen Ortega –

  4. Timothy Miles –

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