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From the musculoskeletal system:
arthralgia and myalgia.
From the skin and subcutaneous tissues:
rashes, including maculopapular and erythematous, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, photosensitivity reactions and photonycholysis.
From the urinary system:
increased concentration of urea in the blood.
when using almost all antibacterial drugs, excessive growth of insensitive microorganisms can cause candidiasis, glossitis, staphylococcal enterocolitis, pseudomembranous colitis (with excessive growth of Clostridium difficile) and inflammatory changes (with excessive growth of Candida fungi) in the anogenital region. Also, cases of stomatitis and vaginitis were noted when using tetracycline preparations.
shortness of breath, redness (of the face), peripheral edema, exacerbation of systemic lupus erythematosus; with prolonged treatment, tetracyclines caused thyroid tissue to turn brown-black on microscopic examination, cases of thyroid dysfunction are not known.
Contraindications to use
pregnancy; lactation;newborns and children under the age of 12; hypersensitivity to doxycycline, auxiliary components of the drug or any other tetracyclines.
Use during pregnancy and lactation
The use of the drug is contraindicated during pregnancy. The risk associated with the use of tetracyclines during pregnancy is mainly associated with exposure during the development of teeth and musculoskeletal system.
Since tetracyclines are excreted in breast milk, the use of the drug is contraindicated for women who are breastfeeding.
Use in cases of impaired liver function
Vibramycin should be used with caution in patients with impaired liver function or in patients receiving treatment with drugs with potential hepatotoxic effects.