Description

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Indications of the drug Wellbutrin

treatment of depression. When an adequate response is achieved, the continuation of bupropion therapy for the prevention of exacerbations and relapses of depressive episodes.

Dosage regimen

Prolonged-acting bupropion tablets should be swallowed whole, without chewing, breaking or grinding, as this may lead to an increased risk of adverse reactions, including convulsive disorders.

Treatment of depression

The clinical effect appears 14 days after the start of therapy. As with all antidepressants, the antidepressant effect may occur after several weeks of treatment.

The maximum single dose of delayed-release bupropion should be no more than 450 mg. The interval between bupropion doses should be at least 24 hours after the last intake. The dose should not be increased by more than 100 mg per day for three days.

Adults

The beginning of treatment

The initial dose of bupropion is 150 mg once a day, in the morning.

If an adequate therapeutic response is not achieved, it is recommended to increase the dose to the usual target dose for adults of 300 mg / day 1 time per day.

Increasing the dose above 300 mg/ day

Increasing the dose to a maximum daily dose of 450 mg 1 time / day is possible for patients who have no clinical improvement after several weeks of therapy at a dose of 300 mg / day.

Supportive therapy

Acute episodes of depression require continuous treatment lasting from 6 months after the initial therapeutic response is achieved. The effectiveness of bupropion (300 mg / day) has been proven with long-term therapy (up to 1 year).

Children and teenagers

The safety and efficacy of bupropion in patients under the age of 18 has not been established.

Treatment of depression in special groups of patients

Elderly patients

Elderly patients are more likely to develop a hypersensitivity reaction, therefore, the dose or frequency of taking the drug should be reduced.