Description
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Side Effect
From the side of the organ of vision – Very often: hyperpigmentation of the iris, conjunctival hyperemia, mild to moderate eye irritation (burning sensation, feeling of sand in the eyes, itching, tingling and sensation of a foreign body), eyelash changes (increase in length, thickness, quantity and pigmentation); Often: transient spot erosion of the epithelium (mostly asymptomatic), blepharitis, eye pain; Infrequently: swelling of the eyelids, dryness of the mucous membrane of the eye, keratitis, blurred vision, conjunctivitis; Rarely: iritis /uveitis (mainly in predisposed patients), macular edema, eyelid edema, corneal edema, corneal erosion, periorbital edema, darkening of the eyelid skin, reactions from the eyelid skin, changes in the direction of eyelash growth, thickening, darkening and lengthening of eyelashes, distichiasis, photophobia; Very rarely: changes in the periorbital region and in the eyelashes, leading to deepening of the furrow of the upper eyelid; Frequency unknown: iris cyst, pseudopemphigoid of the conjunctiva. From the nervous system – The frequency is unknown: dizziness, headache. From the heart – Infrequently: angina pectoris, palpitation sensation; Frequency unknown: unstable angina pectoris. From the respiratory system – Rarely: bronchospasm (including exacerbation of the disease in patients with a history of bronchial asthma), shortness of breath. From the skin and subcutaneous tissues – Infrequently: rash; Rare: itching of the skin; Very rare: darkening of the eyelid skin and local skin reactions on the eyelids. From the musculoskeletal system and connective tissue – The frequency is unknown: myalgia, arthralgia. General disorders and local reactions are very rare: chest pain. Children According to the results of two short-term (< 12 weeks) clinical studies in 93 children, the safety profile of latanoprost in children did not differ from the safety profile in adults. The safety profile between different age groups in children is comparable. Compared with the adult population, children most often had nasopharyngitis and fever.
Overdose
Symptoms: in addition to irritation of the mucous membrane of the eyes, hyperemia of the conjunctiva or episclera, other undesirable changes on the part of the organ of vision with an overdose of latanoprost were not noted. In case of accidental ingestion of latanoprost, the following information should be taken into account: one bottle with 2.5 ml of solution contains 125 micrograms of latanoprost. More than 90% of the drug is metabolized during the “first passage” through the liver. Intravenous infusion at a dose of 3 micrograms / kg in healthy volunteers did not cause any symptoms, however, when a dose of 5.5-10 micrograms / kg was administered, nausea, abdominal pain, dizziness, fatigue, hot flashes and sweating were observed. In patients with moderate bronchial asthma, the introduction of latanoprost into the eyes at a dose 7 times higher than the therapeutic dose did not cause bronchospasm. Treatment: symptomatic therapy.
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