Description
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Side Effects
The following adverse reactions are
manifestations of toxicity known for fluoropyrimidine therapy; at least an indirect relationship has been reported between the development of such reactions and the use of Xeloda® in less than 5% of patients participating in 7 completed clinical trials (N=949): From the gastrointestinal tract: dry mouth, flatulence, adverse reactions associated with inflammation / ulceration of the mucous membranes, such as: esophagitis, gastritis, duodenitis, colitis, gastrointestinal bleeding. From the cardiovascular system: edema of the lower extremities, cardialgia, including angina pectoris, cardiomyopathy, myocardial ischemia, myocardial infarction, heart failure, sudden death, tachycardia, supraventricular arrhythmias, including atrial fibrillation, ventricular extrasystoles. From the nervous system: taste disorders, insomnia, confusion, encephalopathy, symptoms of cerebellar disorders (ataxia, dysarthria, balance and coordination disorders). From the side of the psyche: depression. Infectious and parasitic diseases: infectious complications associated with myelosuppression, weakened immunity and/or impaired integrity of the mucous membranes, such as local and fatal systemic infections (bacterial, viral or fungal etiology) and sepsis. From the blood and lymphatic system: anemia, myelosuppression, pancytopenia. From the skin and subcutaneous tissues: itching, focal peeling of the skin, hyperpigmentation of the skin, nail changes, photosensitization reactions, a syndrome resembling radiation dermatitis. From the side of the organ of vision: eye irritation. From the respiratory system: shortness of breath, cough. From the musculoskeletal system and connective tissue: arthralgia, myalgia, back pain. General disorders and disorders at the injection site: asthenia, chest pain (non-cardiac etiology), pain in the extremities, increased drowsiness.
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